Abstract: How to improve the cure rate and survival rate of oral and maxillofacial malignant tumor, and maintain a higher quality of life, have been one of the focus of the scholars study. Radical resection of oral and maxillofacial malignant tumor often leads to severe facial deformity and dysfunction, such as oral cavity, so now the chemotherapy or radiotherapy combined with surgical treatment is often used. In recent years, studies have shown that close range radiotherapy with ¹²⁵I radioactive seed implantation is effective in reducing tumor size and reducing recurrence of oral and maxillofacial malignant tumors. In this paper, the clinical application of ¹²⁵I radioactive seed in the treatment of oral and maxillofacial malignant tumors is described.

Key words: ¹²⁵I radioactive seed, Malignant tumor, Oral and maxillofacial, region Implantation