Research Progress on Relationship between Chronic Periodontitis and Alzheimer’s Disease.

doi:10.13701/j.cnki.kqyxyj.2019.05.002

Abstract

Abstract: Chronic periodontitis is a destructive disease of dental support tissues which originated by dental plaque and generated by host immune-inflammatory responses and other factors. Its occurrence and development are closely associated with general systemic disease. Alzheimer's disease is one of the most common progressive neurocognitive disorder diseases. Recently, studies have found that chronic periodontitis is mutually associated with Alzheimer's disease. In this review, we conclude the correlation between chronic periodontitis and Alzheimer's disease, and summarize the mechanisms how chronic periodontitis participates in and promotes the progression of Alzheimer's disease.

Key words: Chronic periodontitis, Alzheimer’s disease, Porphyromonas gingivalis, Proinflammatory cytokine, Amyloid β-protein

NIE Ran, ZHOU Yan-min. Research Progress on Relationship between Chronic Periodontitis and Alzheimer’s Disease.[J]. Journal of Oral Science Research, 2019, 35(5): 419-422.

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