Comparison of Inflammatory Factors and Immune Function between HIV-infected and Non-HIV-infected Patients with Chronic Apical Periodontitis.

doi:10.13701/j.cnki.kqyxyj.2019.05.012

Abstract

Abstract: Objective: To compare the differences of inflammatory factors and immune function between HIV-infected and non-HIV-infected patients with chronic apical periodontitis. Methods: The excised pathological tissues were obtained from the teeth of 48 patients (24 HIV-infected patients and 24 non-HIV-infected patients) with chronic apical periodontitis. No patients were treated with preoperative endodontic treatment. The samples were histopathologically and immunohistochemically analyzed by an optical microscope. The immune expression was divided into 2 levels: focal to weak and moderate to strong. Results: The expressions of CD3, CD4, CD8, CD68, IFN-g, IL-6, and IL-18 in HIV-infected group were lower than those in non-HIV-infected group, and the expression of TNF-α in infected group was higher than that in non-HIV-infected group (P<0.05). There was no significant difference in CD20 expression between two groups (P>0.05). Conclusion: HIV infection has an effect on the expression of inflammatory factors and immune function in patients with chronic apical periodontitis.

Key words: HIV infection, Chronic apical periodontitis, Immunohistochemistry, Inflammatory factors, Immune function

ZHAO Heng-yue, HE Wen-juan. Comparison of Inflammatory Factors and Immune Function between HIV-infected and Non-HIV-infected Patients with Chronic Apical Periodontitis.[J]. Journal of Oral Science Research, 2019, 35(5): 461-465.

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