Expression of CYP27B1 in Oral Squamous Cell Carcinoma and Its Relationship with Prognosis

doi:10.13701/j.cnki.kqyxyj.2020.10.010

Abstract

Abstract: Objective: To investigate the expression of CYP27B1 in oral squamous cell carcinoma (OSCC) and its correlation with prognosis. Methods: The data of 372 patients with OSCC were downloaded from the TCGA (the cancer genome atlas) database as a TCGA database cohort to extract the CYP27B1 gene expression-related data of the above-mentioned patients. The differences of CYP27B1 expression in cancer and adjacent tissues of OSCC patients were calculated and analyzed using the edgR package. 146 patients with OSCC in the Department of Stomatology, Xinqiao Hospital (Second Affiliated Hospital of Army Military Medical University) were selected as a Xinqiao Hospital cohort. The paraffin sections of the patients were immunohistochemical stained, and the expression of CYP27B1 was detected. According to the CYP27B1 expression results, the median value of OSCC patients was divided into CYP27B1 high expression and CYP27B1 low expression group. Combined with the clinical medical records, the relationship between CYP27B1 expression and prognosis was analyzed. Results: CYP27B1 was expressed in OSCC tissues both in TCGA database cohort and Xinqiao Hospital cohort. Kaplan-meier survival analysis showed that the overall survival time (OS) of the group with high expression of CYP27B1 was significantly higher than that of the group with low expression (P<0.05). Conclusion: CYP27B1 poor expression may relate to the occurrence, development, and prognosis of OSCC.

Key words: oral squamous cell carcinoma, CYP27B1, prognosis

GUO Junfeng, ZHANG Gang, TAN Yinghui. Expression of CYP27B1 in Oral Squamous Cell Carcinoma and Its Relationship with Prognosis[J]. Journal of Oral Science Research, 2020, 36(10): 930-933.

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