Application of Poly(lactic-co-glycolic acid) Copolymer Microspheres in Bone Tissue Engineering

doi:10.13701/j.cnki.kqyxyj.2020.09.005

Abstract

Abstract: As a kind of composite material, Poly(lactic-co-glycolic acid) (PLGA) copolymer has biocompatibility, low toxicity, and the ability to encapsulate and protect biological factors. Based on the physical and chemical properties of PLGA, the synthesis of PLGA microspheres and its application in bone tissue engineering are reviewed in this paper, with hope to provide reference for the application of PLGA in bone tissue engineering.

Key words: poly(lactic-co-glycolic acid) copolymer nanoparticle, bone tissue engineering, nanoparticle

WANG Jianqun, ZHANG Bin. Application of Poly(lactic-co-glycolic acid) Copolymer Microspheres in Bone Tissue Engineering[J]. Journal of Oral Science Research, 2020, 36(9): 817-820.

References

[1] Wahajuddin SA. Superparamagnetic iron oxide nanoparticles: magnetic nanoplatforms as drug carriers [J]. Int J Nanomedicine,2012,7:3445-3471.
[2] Gentile P, Chiono V, Carmagnola I, et al. An overview of poly (lactic-co-glycolic) acid (PLGA)-based biomaterials for bone tissue engineering [J]. Int J Mol Sci, 2014, 15(3): 3640-3659.
[3] Meng FT, Ma GH, Liu YD, et al. Microencapsulation of bovine hemoglobin with high bio-activity and high entrapment efficiency using a W/O/W double emulsion technique [J]. Colloids Surf B Biointerfaces, 2004, 33(3-4): 177-183.
[4] Makadia HK, Siegel SJ. Poly lactic-co-glycolic acid (PLGA) as biodegradable controlled drug delivery carrier [J]. Polymers (Basel), 2011, 3:1377-1397.
[5] Raghuvanshi RS, Katare YK, Lalwani K, et al. Improved immune response from biodegradable polymer particles entrapping tetanus toxoid by use of different immunization protocol and adjuvants [J]. Int J Pharm, 2002, 245(1-2): 109-121.
[6] Wiggins JS, Hassan MK, Mauritz KA, et al. Hydrolytic degradation of poly (d, l-lactide) as a function of end group: Carboxylic acid vs. hydroxyl [J]. Polymer, 2006, 47(6): 1960-1969.
[7] Quintanar-Guerrero D, Allémann E, Fessi H, et al. Preparation techniques and mechanisms of formation of biodegradable nanoparticles from preformed polymers [J]. Drug Dev Ind Pharm, 1998, 24(12): 1113-1128.
[8] Sanna V, Roggio AM, Pala N, et al. Effect of chitosan concentration on PLGA microcapsules for controlled release and stability of resveratrol [J]. Int J Biol Macromol, 2015, 72: 531-536.
[9] Kolte A, Patil S, Lesimple P, et al. PEGylated composite nanoparticles of PLGA and polyethylenimine for safe and efficient delivery of pDNA to lungs [J]. Int J Pharm, 2017, 524(1-2): 382-396.
[10] van de Weert M, Hoechstetter J, Hennink WE, et al. The effect of a water/organic solvent interface on the structural stability of lysozyme [J]. J Control Release, 2000, 68(3): 351-359.
[11] Varshochian R, Jeddi-Tehrani M, Mahmoudi AR, et al. The protective effect of albumin on bevacizumab activity and stability in PLGA nanoparticles intended for retinal and choroidal neovascularization treatments [J]. Eur J Pharm Sci, 2013, 50(3-4): 341-352.
[12] Stanwick JC, Baumann MD, Shoichet MS. Enhanced neurotrophin-3 bioactivity and release from a nanoparticle-loaded composite hydrogel [J]. J Control Release, 2012, 160(3): 666-675.
[13] Son S, Lee WR, Joung YK, et al. Optimized stability retention of a monoclonal antibody in the PLGA nanoparticles [J]. Int J Pharm, 2009, 368(1-2): 178-185.
[14] Leon RAL, Somasundar A, Badruddoza AZM, et al. Microfluidic fabrication of multi-drug-loaded polymeric microparticles for topical glaucoma therapy [J]. Part Part Syst Char, 2015, 32(5): 567-572.
[15] Xu Q, Hashimoto M, Dang TT, et al. Preparation of monodisperse biodegradable polymer microparticles using a microfluidic flow-focusing device for controlled drug delivery [J]. Small, 2009, 5(13): 1575-1581.
[16] Wang W, Miao Y, Zhou X, et al. Local delivery of BMP-2 from poly (lactic-co-glycolic acid) microspheres incorporated into porous nanofibrous scaffold for bone tissue regeneration [J]. J Biomed Nanotechnol, 2017, 13(11): 1446-1456.
[17] Chen J, Liu M, Duan X, et al. Effect of bone morphogenetic protein 7/poly (lactide-co-glycolide) microspheres on the in vitro proliferation and chondrogenic differentiation of rabbit bone marrow mesenchymal stem cells [J]. Zhongguo xiu fu chong jian wai ke za zhi, 2018, 32(4): 428-433.
[18] 张轲. 骨形态发生蛋白2,7-聚乳酸-羟基乙酸共聚物复合支架的制备及其细胞成骨能力研究[D].泸州:西南医科大学,2016.
[19] Ribeiro S, Hussain N, Florence AT. Release of DNA from dendriplexes encapsulated in PLGA nanoparticles [J]. Int J Pharm, 2005, 298(2): 354-360.
[20] Kim IS, Lee SK, Park YM, et al. Physicochemical characterization of poly (L-lactic acid) and poly (D, L-lactide-co-glycolide) nanoparticles with polyethylenimine as gene delivery carrier [J]. Int J Pharm, 2005, 298(1): 255-262.
[21] Qiao C, Zhang K, Jin H, et al. Using poly (lactic-co-glycolic acid) microspheres to encapsulate plasmid of bone morphogenetic protein 2/polyethylenimine nanoparticles to promote bone formation in vitro and in vivo [J]. Int J Nanomedicine, 2013, 8: 2985.
[22] Sezlev Bilecen D, Uludag H, Hasirci V. Development of PEI-RANK siRNA complex loaded PLGA nanocapsules for the treatment of osteoporosis [J]. Tissue Eng Part A, 2019, 25(1-2): 34-43.
[23] Zhang HX, Xiao GY, Wang X, et al.Biocompatibility and osteogenesis of calcium phosphate composite scaffolds containing simvastatin-loaded PLGA microspheres for bone tissue engineering [J]. J Biomed Mater Res A,2015,103(10):3250-3258.
[24] 邱晓明.β-磷酸三钙支架负载万古霉素/PLGA微球治疗感染性骨缺损的实验研究[D].兰州:兰州大学,2018.
[25] 屈墨羱.大孔聚乳酸-羟基乙酸共聚物(PLGA)微球修复软骨缺损[A].中华口腔医学会颞下颌关节病学及牙合学专业委员会.中华口腔医学会第十五次全国颞下颌关节病学及牙合学学术研讨会论文汇编[C].中华口腔医学会颞下颌关节病学及牙合学专业委员会:中华口腔医学会,2018:1.
[26] Zhang F, Li Q, Lin Z, et al. Engineered Fe(OH)₃ nanoparticle-coated and rhBMP-2-releasing PLGA microsphere scaffolds for promoting bone regeneration by facilitating cell homing and osteogenic differentiation [J]. J Mater Chem B, 2018, 6(18): 2831-2842.