Application of Nanofibrous Scaffold in Bone Tissue Engineering

doi:10.13701/j.cnki.kqyxyj.2018.08.002

Abstract

Abstract: Nanofibrous scaffolds, which are porous and hierarchical, have been widely used in bone tissue engineering in recent years. Bone tissue engineering consists of three parts: suitable seed cells, scaffolds, and growth factors. The research on bone tissue engineering focused on finding three-dimensional tissue engineering scaffolds to promote cell growth and guide bone regeneration. Since nanofibrous scaffolds, which are similar to the extracelluar matrix of natural bone in morphology and structure, can promote cell adhesion and stem cell differentiation, they have become ideal scaffolds in bone regeneration in recent years. In this paper, we review the fabrication technologies of nanofibrous scaffolds and their advanced applications.

Key words: Bone tissue engineering, Nanofiber, Scaffold, Biomimetic material

HUANG Shan, LIU Hong. Application of Nanofibrous Scaffold in Bone Tissue Engineering[J]. Journal of Oral Science Research, 2018, 34(8): 809-811.

References

[1] Amini AR, Laurencin CT, Nukavarapu SP. Bone tissue engineering: recent advances and challenges [J]. Crit Rev Biomed Eng, 2012, 40(5)∶363-408
[2] Holzwarth JM, Ma PX. Biomimetic nanofibrous scaffolds for bone tissue engineering [J]. Biomaterials, 2011, 32(36)∶9622-9629
[3] Harvey EJ, Henderson JE, Vengallatore ST. Nanotechnology and bone healing [J]. J Orthop Trauma, 2010, 24, 1(3)∶25-30
[4] Yang X, Chen X, Wang H. Acceleration of osteogenic differentiation of preosteoblastic cells by chitosan containing nanofibrous scaffolds [J]. Biomacromolecules, 2009, 10(10)∶2772-2778
[5] Asli MM, Pourdeyhimi B, Loboa EG. Release profiles of tricalcium phosphate nanoparticles from poly(L-lactic acid) electrospun scaffolds with single component, core-sheath, or porous fiber morphologies: effects on hASC viability and osteogenic differentiation [J]. Macromol Biosci, 2012, 12(7)∶893-900
[6] Chen R, Huang C, Ke Q, et al. Preparation and characterization of coaxial electrospun thermoplastic polyurethane/collagen compound nanofibers for tissue engineering applications [J]. Colloids Surf B Biointerfaces, 2010, 79(2)∶315-325
[7] Briggs T, Arinzeh TL. Examining the formulation of emulsion electrospinning for improving the release of bioactive proteins from electrospun fibers [J]. J Biomed Mater Res A, 2014, 102(3)∶674-684
[8] Mcclellan P, Landis WJ. Recent applications of coaxial and emulsion electrospinning methods in the field of tissue engineering [J]. Biores Open Access, 2016, 5(1)∶212-227
[9] Ma PX, Zhang R. Synthetic nano-scale fibrous extracellular matrix [J]. J Biomed Mater Res, 1999, 46(1)∶60-72
[10] 刘瑞来, 陈良壁, 唐春怡. 三维纳米纤维组织工程支架的研究进展[J].德州学院学报, 2014, 30(4)∶57-62
[11] Wei G, Ma PX. Macroporous and nanofibrous polymer scaffolds and polymer/bone-like apatite composite scaffolds generated by sugar spheres [J]. J Biomed Mater Res A, 2006, 78A(2)∶306-315
[12] Chen VJ, Smith LA, Ma PX. Bone regeneration on computer-designed nano-fibrous scaffolds [J]. Biomaterials, 2006, 27(21)∶3973-3979
[13] Akbarzadeh R, Yousefi AM. Effects of processing parameters in thermally induced phase separation technique on porous architecture of scaffolds for bone tissue engineering [J]. J Biomed Mater Res B Appl Biomater, 2014, 102(6)∶1304-1315
[14] Guo J, Liu X, Lee MA, et al. Novel porous poly(propylene fumarate-co-caprolactone) scaffolds fabricated by thermally induced phase separation [J]. J Biomed Mater Res A, 2016, 105(1)∶226-235
[15] 张震, 李莹, 耿亚伟,等. 纳米支架及合成技术在神经组织再生的应用[J].口腔医学研究,2017,33(4)∶459-462
[16] 何彬, 袁霄, 张华,等. 自组装肽纳米纤维支架用于骨修复的研究进展[J].中国修复重建外科杂志,2014,28(10)∶1303-1306
[17] He B, Ou Y, Zhou A, et al. Functionalizedd-form self-assembling peptide hydrogels for bone regeneration [J]. Drug Des Devel Ther, 2016, 10(1)∶1379-1388
[18] Wang Z, Dong L, Han L, et al. Self-assembled biodegradable nanoparticles and polysaccharides as biomimetic ECM nanostructures for the synergistic effect of RGD and BMP-2 on bone formation [J]. Sci Rep, 2016, 6∶25090
[19] Igwe JC, Mikael PE, Nukavarapu SP. Design, fabrication and in vitro, evaluation of a novel polymer-hydrogel hybrid scaffold for bone tissue engineering [J]. J Tissue Eng Regen Med, 2014, 8(2)∶131-142
[20] Lee SH, Lim YM, Jeong SI, et al. The effect of bacterial cellulose membrane compared with collagen membrane on guided bone regeneration [J]. J Adv Prosthodont, 2015, 7(6)∶484-495
[21] Lee YJ, An SJ, Bae EB, et al. The effect of thickness of resorbable bacterial cellulose membrane on guided bone regeneration [J]. Materials (Basel), 2017, 10(3) ,pii: E320
[22] Saska S, Barud HS, Gaspar AM, et al. Bacterial cellulose-hydroxyapatite nanocomposites for bone regeneration [J]. Int J Biomater,2011, 2011∶1-8
[23] Grande CJ, Torres FG, Gomez CM, et al. Nanocomposites of bacterial cellulose/hydroxyapatite for biomedical applications [J]. Acta Biomater, 2009, 5(5)∶1605-1615
[24] Helenius G, Bäckdahl H, Bodin A, et al. In vivo biocompatibility of bacterial cellulose [J]. J Biomed Mater Res A, 2006, 76A(2)∶431-438
[25] Zhijiang C, Chengwei H, Guang Y. Preparation and characterization of a bacterial cellulose/chitosan composite for potential biomedical application [J]. J Polym Res, 2011, 18(4)∶739-744