Research Progress on Functional Composite Scaffolds in Bone Tissue Engineering

doi:10.13701/j.cnki.kqyxyj.2025.05.003

Abstract

Abstract: Autologous bone grafting, as the clinical "gold standard" for the treatment of major bone defects, still has limitations including limited donor sites and the extra trauma. Functional composite scaffolds in bone tissue engineering are characterized by high mechanical strength and biocompatibility, etc. Various substances, such as cell growth factors, drugs, and metal ions, endow the scaffolds with biological features of proliferation promoting, anti-inflammation, and osteogenesis. The resulting functional composite scaffolds provide a new alternative for the treatment of bone defects, which is expected to replace autologous bone. This study summarizes the latest research of various functional composite scaffolds in bone tissue engineering in recent years, providing reference and strategy for the follow-up design and application of functional composite scaffolds.

Key words: bone tissue engineering, bone defect repair, functional composite scaffolds

NIU Delong, LIU Zhonghao. Research Progress on Functional Composite Scaffolds in Bone Tissue Engineering[J]. Journal of Oral Science Research, 2025, 41(5): 373-377.

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