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Prediction of Potential Targets and Molecular Mechanisms of Compound Honeysuckle in Prevention and Treatment of Periodontitis Based on Network Pharmacology and Molecular Docking Technology XIANG Jing, CHEN Qihang, QIANG Xiaoye, WANG Shuxin, ZHANG Dejun Journal of Oral Science Research    2025, 41 (1): 26-34.   DOI: 10.13701/j.cnki.kqyxyj.2025.01.006 Abstract （1093）      PDF （5942KB）（1934）       Objective: To screen the potential active components and molecular mechanisms of Compound Honeysuckle by network pharmacology in preventing and treating periodontitis and to verify the inhibitory effect of compound honeysuckle on Porphyromonas gingivalis (Pg) through experimental validation. Methods: Active components and targets were screened using multiple databases combined with ADME and Lipinski's rules. A drug-active component-target network was constructed, and core targets were identified through the PPI network. GO and KEGG enrichment analyses were used to explore the functions and pathways of the targets. Molecular docking was used to validate the binding activity between active components and target proteins. The inhibitory effect of compound honeysuckle on Pg was determined using the broth microdilution method. Results: A total of 38 active components of compound honeysuckle were identified, with key targets including AKT serine/threonine kinase 1 (AKT 1), epidermal growth factor receptor erbB1 (EGFR),and heat shock protein 90 alpha family class A member 1 (HSP90AA1). KEGG analysis indicated that compound honeysuckle may exert its effects through the regulation of the phosphatidylinositol 3-kinase/Akt Pathway (PI3K-Akt), calcium signaling pathways, and cancer-related pathways. Molecular docking confirmed good binding affinity between key compounds and targets. In vitro experiments showed that the MIC and MBC of compound honeysuckle against Pg were both 5.469 mg/mL. Conclusion: Compound honeysuckle shows potential in preventing and treating periodontitis through the modulation of multiple targets and signaling pathways, providing a theoretical basis for further research and clinical applications. Reference | Related Articles | Metrics

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Oral Mucosal Diseases in the Era of Intelligence: Current Status and Prospects of Artificial Intelligence Applications in Research YANG Qingmo, WEI Pan, HUA Hong Journal of Oral Science Research    2025, 41 (1): 1-6.   DOI: 10.13701/j.cnki.kqyxyj.2025.01.001 Abstract （980）      PDF （822KB）（1546）       With the development of artificial intelligence (AI) technology, its integrated application in the medical field has received widespread attention. Medical artificial intelligence plays an increasingly important role in image recognition, disease diagnosis, risk prediction, and provision of health consulting services. The diagnosis and evaluation of oral mucosal diseases are highly dependent on morphological characteristics, and AI has broad application prospects in this field. This article reviews the application of AI in auxiliary diagnosis and risk prediction of oral mucosal diseases, and analyzes and prospects the current challenges and future development trends, in order to provide reference for future AI-related research on oral mucosal diseases. Reference | Related Articles | Metrics

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Role and Mechanism of Fusobacterium Nucleatum in Oral Mucosal Carcinogenesis QUBIE Fangfang, JIANG Lu Journal of Oral Science Research    2024, 40 (5): 379-384.   DOI: 10.13701/j.cnki.kqyxyj.2024.05.001 Abstract （467）      PDF （1103KB）（1385）       Oral mucosal carcinogenesis is a serious health issue involving multiple factors in its onset and progression. In recent years, fusobacterium nucleatum ( F.nucleatum), as a part of the oral microbiota, has been considered as one of the infectious agents playing a significant role in various cancers. This review aims to comprehensively explore the role and mechanisms of F.nucleatum in oral mucosal carcinogenesis. Through the analysis of clinical and molecular biology studies, we found that F.nucleatum is closely related to the occurrence and development of oral potentially malignant disorders (OPMD) and oral squamous cell carcinoma (OSCC). Specifically, this bacterium can modulate the tumor immune microenvironment, promote cell proliferation and invasion, and activate immune checkpoints. Additionally, F.nucleatum may serve as a biomarker and therapeutic target for oral cancer. However, research in this field still faces challenges such as insufficient sample size, strong patient specificity, and the need for multidisciplinary collaboration. Future studies are needed to further reveal its mechanisms and explore its potential applications in the prevention and treatment of oral cancer. Reference | Related Articles | Metrics

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Eupatilin Inhibits RANKL-induced Osteoclast Differentiation by Regulating MAPK and NF-κB Signaling Pathways ZHAO Boxuan, LI Ting, YAO Hantao, WANG Zijun, GUO Haiying, JI Yaoting, DU Minquan Journal of Oral Science Research    2024, 40 (9): 820-826.   DOI: 10.13701/j.cnki.kqyxyj.2024.09.012 Abstract （455）      PDF （5750KB）（1284）       Objective: To investigate the effects and molecular mechanisms of eupatilin on the differentiation of osteoclast precursor cells to osteoblasts. Methods: CCK-8 assay was used to detect the effects of different concentrations of Eupatilin on the cell activity of osteoclast precursor cells RAW264.7 and mouse bone marrow-derived macrophages (BMDMs). RAW264.7 and BMDMs were induced to differentiate into osteoclasts by receptor activator of nuclear factor-κB ligand (RANKL), and different concentrations of Eupatilin (5, 10, and 20 μmol/L) were used for intervention. The effects of Eupatilin on RANKL-induced osteoclast formation were evaluated through TRAP staining and F-actin staining. The expression of osteoclast-related marker genes was detected by qRT-PCR and Western blot, and the phosphorylation levels of mitogen-activated protein kinase (MAPK) and nuclear factor-κB (NF-κB) signaling pathway molecules were detected by Western blot. Results: Eupatilin at 20 μmol/L exhibited a significant inhibitory effect on the differentiation of osteoclasts, and also shown an effective downregulation of the expression of related marker genes such as tartrate-resistant acid phosphas (TRAP), matrix metalloproteinase-9 (MMP-9), and cathepsin K (CTSK). Western blot results indicated that Eupatilin significantly inhibited the phosphorylation levels of MAPK and NF-κB signaling pathway molecules induced by RANKL. Conclusion: Eupatilin exerts a significant inhibitory effect on RANKL-induced osteoclast differentiation by regulating the MAPK and NF-κB signaling pathways. Reference | Related Articles | Metrics

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An Update on Research Progress of Chlorhexidine Reduced Susceptibility in Oral Bacteria and Relative Mechanisms REN Jingyi, ZHOU Wenjuan Journal of Oral Science Research    2024, 40 (8): 670-675.   DOI: 10.13701/j.cnki.kqyxyj.2024.08.002 Abstract （511）      PDF （898KB）（1239）       Chlorhexidine (CHX) is the most widely applicated biocide for clinical surface disinfection, however, there is a lack of regulations on its usage. The long-term and extensive utilization of CHX has led to the reduced susceptibility against CHX and cross-resistance towards an array of critical antibiotics in clinical isolates of multiple essential pathogens related to nosocomial infections. However, the potential resistance risk in oral bacteria has been overlooked even though CHX has been applied as the gold standard in dentistry for over 50 years. Hence, the current review aims to summarize the evidence of the reduced susceptibility to CHX in oral bacteria and elucidate the relative mechanisms to raise the concern about its potential risk in dental practice. Reference | Related Articles | Metrics

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Research Progress of PKM2 in Odontogenic Keratocysts WANG Haojun, ZHA Guangyu Journal of Oral Science Research    2024, 40 (11): 956-959.   DOI: 10.13701/j.cnki.kqyxyj.2024.11.003 Abstract （409）      PDF （840KB）（1093）       The odontogenic keratocyst (OKC) is a developmental cyst that has high potential for invasiveness, easy recurrence, and multiple occurrences. Its energy metabolism pathway is mainly glycolysis. Pyruvate kinase M2 (PKM2) is a key driving factor of glycolysis and plays an important role in regulating the tumor metabolic microenvironment. The traditional Chinese medicine (TCM) has a long history of treating tumors with its unique theory of "steady-state" effect on the tumor immune microenvironment. This review will delve into the regulation of PKM2 in respect of odontogenic keratocysts, aiming to provide new ideas for the clinical treatment of OKC with traditional Chinese medicine. Reference | Related Articles | Metrics

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Research Progress on Predisposing Factors of Peri-implantitis SUN Yuyan, MENG Weiyan Journal of Oral Science Research    2024, 40 (5): 389-392.   DOI: 10.13701/j.cnki.kqyxyj.2024.05.003 Abstract （502）      PDF （799KB）（1090）       With the development of oral implantology, implantation has become an ideal method for the restoration of dentition defect and edentulous jaw. However, the occurrence and progression of peri-implantitis directly influence the long-term success rate of implant restoration. Factors including host (genetic factors, medical history, personal habits, etc.), surgery (three-dimensional positioning of the implant, etc.), and restoration (prosthesis fixation method, morphological design, etc.) are critical to influence and regulate peri-implantitis. This article provides comprehensive review of the risk factors associated with peri-implantitis, aiming to provide theoretical basis and clinical strategies for the prevention and treatment of peri-implantitis. Reference | Related Articles | Metrics

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A Case Report of Initial Periodontal Therapy for Generalized Severe Periodontitis (Stage Ⅱ Grade B) WU Jing, NA Xin, PENG Simin, CAO Zhengguo, WANG Xiaoxuan Journal of Oral Science Research    2025, 41 (3): 260-264.   DOI: 10.13701/j.cnki.kqyxyj.2025.03.016 Abstract （390）      PDF （5060KB）（953）       This article systematically documents the complete treatment process of a case with generalized stage Ⅱ grade B periodontitis, following the S3-level clinical practice guidelines of the European Federation of Periodontology (EFP). By demonstrating the synergistic effects of initial periodontal therapy and supportive periodontal care (SPC), we aim to enhance dental practitioners' understanding of standardized periodontal treatment. Clinical practice has proven that standardized initial periodontal therapy combined with long-term SPC monitoring can effectively control disease progression, maintain treatment outcomes, and reduce recurrence risk. This systematic treatment approach provides a reliable clinical solution for reducing the burden of periodontal diseases. Reference | Related Articles | Metrics

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Vascularization-related Pathogenesis and Treatment Progress of Osteonecrosis of the Jaw SHI Yixin, CHEN Junyu Journal of Oral Science Research    2025, 41 (2): 85-89.   DOI: 10.13701/j.cnki.kqyxyj.2025.02.001 Abstract （500）      PDF （1164KB）（934）       Osteonecrosis of the jaw is a common oral disease involving the jaw after tooth extraction, injury, and radiotherapy, including osteoradionecrosis and medication-related osteonecrosis of the jaw. Its main clinical manifestations are bone exposure, pain, infection, and pathological fracture. The pathogenesis of osteonecrosis of the jaw involves various hypotheses, among which vascular abnormalities are one of the essential mechanisms. Radiation promotes thrombosis by damaging endothelial cells and creating a hypercoagulable state of blood, which becomes a key link in the initiation of osteoradionecrosis of the jaw. Angiogenesis inhibition plays an important role in the development of medication-related osteonecrosis of jaw and is associated with a variety of cells such as macrophages, endothelial cells, preosteoclasts, and their secreted cytokines. Promoting angiogenesis can alleviate or treat osteonecrosis of the jaw. Regulation of vascular function is expected to be a therapeutic option for osteonecrosis of the jaw. This article reviews the vascular-related pathogenesis of osteonecrosis of the jaw and explores potential applications for therapeutic strategies. Reference | Related Articles | Metrics

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Progress of Anterior Repositioning Splint Therapy for Disc Displacement-related Temporomandibular Disorders WEN Jiayu, WU Feng Journal of Oral Science Research    2024, 40 (10): 861-866.   DOI: 10.13701/j.cnki.kqyxyj.2024.10.003 Abstract （725）      PDF （1065KB）（925）       Currently, the prevalence of temporomandibular joint disorders is high and affects the quality of life of patients, of which anterior disc displacement (ADD) of the temporomandibular joint (TMJ) accounts for a large proportion. Anterior repositioning splint (ARS) is considered to be one of the effective conservative treatments for ADD, which effectively relieves clinical symptoms such as pain and popping, and improves the range of motion of the jaw. Due to the wide application of this therapy, its exact mechanism has attracted increasing attention. However, the existing operation methods of ARS, its therapeutic mechanism, and its long-term efficacy are not yet finalized. In view of the current different opinions on ARS treatment, this review attempts to provide research advances in ARS-related treatments to help clinicians understand and select appropriate operational methods. Reference | Related Articles | Metrics

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3-year Clinical Efficacy Analysis of iRoot BP plus Pulp Capping Treatment for Deep Caries of Permanent Teeth LI Peng, SHEN Zhengyan, ZHANG Lei, SUN Qiong Journal of Oral Science Research    2024, 40 (10): 909-913.   DOI: 10.13701/j.cnki.kqyxyj.2024.10.012 Abstract （672）      PDF （1135KB）（871）       Objective: To observe the clinical efficacy of iRoot BP plus pulp capping treatment for deep caries of permanent teeth after 3 years, and to explore the feasibility and influencing factors of this treatment method. Methods: One hundred and twelve mature permanent teeth diagnosed with deep caries or reversible pulpitis were selected from our department from January 2019 to September 2020. The caries were selectively removed under a dental surgical microscope and pulp capping treatment was completed. The follow-up period was more than 3 years, and the treatment effect was evaluated through imaging examinations and clinical indicators. Kaplan Meier survival analysis was used to calculate the survival rate of live pulp, and χ 2 test was used to examine the impact of various variables on clinical efficacy. Results: The Kaplan Meier survival curve showed that the 3-year survival rate of 112 mature permanent teeth after pulp capping was 91.1%, 82 affected teeth underwent indirect pulp capping, and 30 affected teeth underwent direct pulp capping after pulp exposure during caries removal. The 3-year survival rates were 92.7% and 86.7%, respectively. The efficacy of pulp capping was not correlated with gender, age, preoperative diagnosis, tooth type (anterior teeth, premolars, molars), cavity shape (Class Ⅰ, Ⅱ, Ⅲ), tooth position, and pulp capping method ( P>0.05). Conclusion: iRoot BP plus as a pulp capping agent has a good therapeutic effect on mature permanent teeth diagnosed with deep caries or reversible pulpitis, and the study variables have no significant impact on prognosis. Reference | Related Articles | Metrics

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EGCG Crosslinked Biomimetic Mineralized Decellularized Matrix of Filefish Skin As A Membrane for Guided Bone Tissue Regeneration SHEN Shengjie, SUN Ning, XIAO Ting, LI Quanli Journal of Oral Science Research    2024, 40 (5): 448-455.   DOI: 10.13701/j.cnki.kqyxyj.2024.05.013 Abstract （351）      PDF （7104KB）（865）       Objective: To construct decellularized matrix of filefish skin and crosslink it to be biomimetic mineralization template as a guided bone regeneration membrane. Methods: Filefish skin of marine origin was selected, and the decellularized matrix of filefish skin (filefish skin decellularized matrix,FS-ECM) was prepared by a combined physicochemical method. The structural features of FS-ECM were preliminarily explored by HE staining, scanning electron microscope (SEM), X-ray diffraction (XRD), and water contact angle. Then, the cross-linking modification of epigallocatechin gallate (EGCG) was utilized (EGCG crosslinked filefish skin decellularized matrix,E-FS-ECM) to improve the material's anti-enzymatic and mechanical properties. The EGCG-collagen in vitro biomimetic mineralization template (EGCG crosslinked biomimetic mineralized filefish skin decellularized matrix, EB-FS-ECM) was constructed through the modification of EGCG, and the collagen biomimetic mineralization strategy was used to further improve the various properties. The differences in the physicochemical properties of the materials before and after modification were evaluated using SEM, mapping, water contact angle, elastic modulus, thermogravimetric analysis, and in vitro degradation. Results: There was no significant difference between the surface structural properties of FS-ECM at different sites ( P>0.05), and FS-ECM contained a certain amount of hydroxyapatite crystals on the outer surface. After the modification by EGCG cross-linking and construction of biomimetic mineralization templates, the hydrophilicity, mechanical strength, thermal stability, and resistance to enzymatic degradation of E-FS-ECM and EB-FS-ECM were significantly higher than those of FS-ECM ( P<0.05). Conclusion: EGCG cross-linking and biomimetic mineralization significantly improved the hydrophilicity, thermal stability, and mechanical strength, and slowed down the degradation rate of FS-ECM. Decellularized matrix of filefish skin through modification is expected to be an suitable material for GBR membranes. Reference | Related Articles | Metrics

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Study on Effect of Internal Surface Treatment on Bonding Properties and Aesthetic Properties of Super-translucent Zirconia ZHOU Yu, WANG Yaoyao, CHEN Zijie, LIU Lu, HAO Pengjie Journal of Oral Science Research    2025, 41 (5): 406-412.   DOI: 10.13701/j.cnki.kqyxyj.2025.05.009 Abstract （344）      PDF （2710KB）（861）       Objective: To compare the effects of three internal surface treatments on the adhesive properties and aesthetic properties of super-translucent zirconia. Methods: Super-translucent zirconia was cut into different sizes as test standard specimens, and three surface treatments (airborne-particle abrasion, lithium disilicate coating, and glaze on) were selected, followed by fracture test and color measurement. The experimental data were analyzed by two-factor ANOVA and post hoc multiple comparisons (LSD test) for comparison of means between groups. Results: Bond strength was lithium disilicate coating group > glazed group > sandblasted group > control group, and color difference was sandblasted group > glazed group > lithium disilicate coating group. Conclusion: The bonding strength after lithium disilicate coating treatment was significantly greater than that of sandblasted group and glazed group, while the color difference was smaller than that of sandblasted group and glazed group, which was less than the clinically acceptable threshold. Without considering other conditions, it is recommended that lithium disilicate coating be preferred when choosing the appropriate internal surface treatment. Reference | Related Articles | Metrics

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Advances in Prosthetic-guided Peri-implant Soft Tissue Shaping and Transfer Modalities WANG Yuanfan, SUN Xiaojun Journal of Oral Science Research    2025, 41 (2): 90-95.   DOI: 10.13701/j.cnki.kqyxyj.2025.02.002 Abstract （362）      PDF （800KB）（770）       Peri-implant soft tissue shaping can be considered as an effective solution for improving the morphology of peri-implant soft tissues. This technique can help achieve ideal implant aesthetic restorations by guiding the soft tissues to form a shape and contour similar to that of the surrounding natural teeth, based on the soft tissue specifics of the implant site. In this article, the modification and attachment of peri-implant soft tissues in the process of implant restoration, the commonly used prosthetic guided soft tissue shaping methods, and the transfer methods after shaping are reviewed. Reference | Related Articles | Metrics

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Modified Periodontally Accelerated Osteogenic Orthodontics (PAOO) in Treatment of Skeletal Class Ⅱ Malocclusion: A Case Report ZENG Yu, WANG Xiaoxuan, ZHANG Maoqi, ZHANG Aijuan, GAO Ya, XIONG Hui, CAO Zhengguo Journal of Oral Science Research    2025, 41 (8): 727-732.   DOI: 10.13701/j.cnki.kqyxyj.2025.08.016 Abstract （209）      PDF （5715KB）（758）       This article reports a clinical case of skeletal Class Ⅱ malocclusion treated with modified periodontally accelerated osteogenic orthodontics (PAOO). During the presurgical orthodontic decompensation phase, the modified PAOO technique was performed, featuring a papilla-preserving incision design, full-thickness flap elevation, piezocision-assisted interradicular corticotomy, bone augmentation without collagen barrier membrane (using bone graft material alone), and an innovative suturing method. A 24-month follow-up demonstrated significant increases in labial bone plate thickness and keratinized gingiva width at the surgical site, with stable long-term outcomes and no notable gingival recession or severe periodontal inflammatory reactions. The modified protocol effectively reduced surgical trauma and complication risks while ensuring therapeutic efficacy. Reference | Related Articles | Metrics

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Three-dimensional Finite Element Analysis on Effect of Deep Margin Elevation Materials and Heights on First Mandibular Molar Inlay Restoration of Subgingival Defects CAO Liang, ZHAO Ali, WANG Limin, WANG Guangci, ZHANG Guoqing, WANG Weiguo Journal of Oral Science Research    2024, 40 (10): 914-919.   DOI: 10.13701/j.cnki.kqyxyj.2024.10.013 Abstract （356）      PDF （1635KB）（755）       Objective: To evaluate the effects of different deep margin elevation (DME) materials and lifting heights on the biomechanical behavior characteristics of inlay in mandibular first molar with subgingival defects. Methods: Three-dimensional finite element models of mandibular first molars were established based on Micro CT three-dimensional image data. Seven groups of three-dimensional finite element models of mandibular first molar inlay restoration with different DME heights were established through computer-aided design simulation of DME and inlay restoration. The stress distribution and magnitude of each part and interface of the model under two different DME materials (flowable resin and packable resin) and seven different DME heights were studied and compared through three-dimensional finite element simulation analysis. Results: With the increase of DME height, the peak of maximum principal stress (MPS) of the inlay itself continued to rise, while the peak of MPS of the DME layer, the peak of interfacial tensile stress (ITS) between the DME layer and the inlay, and the peak of ITS between the DME layer and the tooth continued to decrease. At the same DME layer height, the peak of MPS of the DME layer, the peak of ITS between the DME layer and the inlay, and the peak of ITS between the DME layer and the tooth were all smaller than those of the packable resin group. The changes in DME layer material and height had no significant effect on other observation indicators. Conclusion: Low elastic modulus DME material and increased DME height are beneficial to reduce the stress of the model and interface. Therefore, it is recommended to choose flowable resin as DME material in clinical operation and appropriately lift the DME layer height. Reference | Related Articles | Metrics

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Changes of Facial Soft Tissue Before and After Orthodontic Treatment in Adult Women Evaluated by Three-dimensional Scanning Technique CAO Yabo, FU Lu, HE Liu, CHEN Qin, CHEN Shuizhen Journal of Oral Science Research    2025, 41 (1): 50-54.   DOI: 10.13701/j.cnki.kqyxyj.2025.01.010 Abstract （410）      PDF （1588KB）（749）       Objective: To evaluate the changes of facial soft tissue before and after orthodontic treatment in adult women by using 3D scanning technology. Methods: A total of 80 adult women who received orthodontic treatment between June 2021 and December 2023 were divided into extraction group and non-extraction group (40 cases each). Before treatment (T0) and after treatment (T1), the two groups underwent facial 3D optical scanning to obtain 3D data of facial soft tissue. The indicators of line distance, angle, and volume of facial soft tissue between two groups before and after treatment were compared. Results: The changes of anterior and lower height, mandibular height, chin height, and lip width line distance in extractive group were smaller than those in non-extractive group ( P<0.05). The changes of nasolabial angle in tooth extraction group were greater than those in non-tooth extraction group ( P<0.05), and those in chin and lip angle were smaller than those in non-tooth extraction group ( P<0.05). The changes of lip and chin volume in extraction group were smaller than those in non-extraction group ( P<0.05). Conclusion: The facial soft tissue of adult women will change in different degrees before and after orthodontic treatment. Three-dimensional scanning technology has good application value in evaluating soft tissue changes before and after orthodontic treatment, and can accurately measure and compare the differences in line distance, angle, and volume of facial soft tissue before and after orthodontic treatment, which is conducive to the development of personalized orthodontic programs. Reference | Related Articles | Metrics

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Smile Aesthetic Outcomes of Infrazygomatic Crest Miniscrews in Patients with Skeletal Class Ⅱ Malocclusions ZHAO Jian, SHI Shuya, LI Chaoqun, LI Xin, HOU Deqiang Journal of Oral Science Research    2024, 40 (11): 967-971.   DOI: 10.13701/j.cnki.kqyxyj.2024.11.005 Abstract （321）      PDF （1270KB）（711）       Objective: To explore the smile aesthetic outcomes of infrazygomatic crest miniscrews in patients with skeletal Class Ⅱ malocclusions. Methods: One hundred and three patients with skeletal Class Ⅱ malocclusions admitted to our hospital from January 2017 to January 2021 were selected and assigned into two groups according to the orthodontic treatment plans. Study group ( n=52) received infrazygomatic crest miniscrews plus straight-wire appliance, while control group ( n=51) was given facebow headgear plus straight-wire appliance. The overall therapeutic efficacy, treatment duration, cephalometric indices six months post-treatment, smile aesthetic effects, and complication rates were compared between the two groups. Results: There was no difference in the success rate of treatment between the two groups ( P>0.05),and the treatment time of the study group (14.3±3.6) was lower than that of the control group (20.1±4.2) ( P<0.05). There was a notable improvement in the angle formed between the long axis of upper central incisor and the lower central incisor (U1-L1), angle formed between the long axis of lower central incisor and the mandibular plane (L1-MP), angle between the long axis of the upper central incisor and the plane of the anterior skull base (U1-SN), point A-Nasion-point B (ANB) angle, maxillary central incisor adduction (U1-Ptm), maxillary molar distal movement (U6-SP), overjet (OJ), and overbite (OB) in both group after treatment. The amount of change in U6-SP was smaller and the amount of change in U1-L1, U1-SN, U1-Ptm and L1-MP was larger in study group than that in control group before and after orthodontic treatment ( P<0.05). There was no statistical difference between two groups in the comparison of the complications such as root resorption, maxillary sinus floor infection, traumatic ulceration, and peri-implantitis ( P>0.05). Conclusion: Application of infrazygomatic crest miniscrews in patients with skeletal Class Ⅱ malocclusions can effectively shorten the orthodontic time, improve the maxillary retraction of anterior teeth, and ameliorate the smile aesthetics. Reference | Related Articles | Metrics

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Research Progress on Facial Aesthetics Subunit Prediction Methods after Orthognathic Surgery LI Jingyi, ZHANG Qian Journal of Oral Science Research    2025, 41 (3): 184-188.   DOI: 10.13701/j.cnki.kqyxyj.2025.03.002 Abstract （341）      PDF （1788KB）（705）       The abnormal appearance caused by dentofacial deformity can have a great psychological impact on patients. Orthognathic surgery is the main surgical method for treating deformity, and the evaluation of its postoperative effects is highly subjective. There are many clinical methods to predict facial changes after surgery. However, due to individual patient differences and software factors, the prediction results of different methods differ in each subunit of the face. The purpose of this review is to explore the research progress of three-dimensional prediction methods and artificial intelligence-based prediction methods for soft tissue after orthognathic surgery in the past ten years, and to evaluate the accuracy of different methods in postoperative prediction of various facial subunits, with a view to providing orthognathic surgeons with the option of surgical virtualization in the future. Reference | Related Articles | Metrics

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Antimicrobial Studies of Liposome Nanoparticles Loaded with Indocyanine Green Against Streptococcus Gordonii In Vitro YANG Qing, CAO Shisheng, GUO Surong, MU Xingtong, ZHAO Cailing, ZHANG Juan Journal of Oral Science Research    2025, 41 (2): 134-139.   DOI: 10.13701/j.cnki.kqyxyj.2025.02.009 Abstract （356）      PDF （5876KB）（699）       Objective: To examine the antibacterial activities of liposomeloaded with indocyanine green (ICG) against streptococcus gordonii using photothermal photodynamic processes in vitro. Methods: The nanoprecipitation method was used to encapsulate ICG in liposomes to obtain indocyanine green nanoparticles (ICG NPs).The particle size and polydispersity index were characterized, and the encapsulation rate of ICG NPs was measured. The photothermal characteristics and generation of reactive oxygen species(ROS) of free ICG and ICG nanoparticles were studied in vitro. Crystal violet staining and colony counting were used to assess the antibacterial efficacy of free ICG and ICG nanoparticles against streptococcus gordonii and to evaluate their effect on biofilm. A test for hemolysis was used to determine the biocompatibility of ICG nanoparticles. Results: ICG NPs had an encapsulation rate of 93.7%, an average particle size of (146±2) nm, and a polydispersity coefficient of 0.263. Compared to the control group, the number of colonies and biofilm biomass gradually decreased with the increase of ICG concentration under NIR irradiation ( P<0.05). Additionally, the ICG NPs exhibited higher antimicrobial (99%) and anti-biofilm (87%) efficiencies. The amount of intracellular ROS gradually increased after different ICG and ICG NPs concentrations were irradiated by 1 W/cm 2 of near-infrared light. ICG NPs had a hemolysis rate of only 3.34%. Conclusion: Periodontal streptococcus gordonii and biofilm can be efficiently destroyed by applying ICG NPs for antimicrobial photodynamic and photothermal therapy. Reference | Related Articles | Metrics