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The S3 Level Clinical Diagnosis and Practice Guideline of Stage Ⅳ Severe Periodontitis Based on 2018 EFP/AAP Classification CAO Zhengguo, GAO Ya, ZENG Yu Journal of Oral Science Research    2023, 39 (11): 943-951.   DOI: 10.13701/j.cnki.kqyxyj.2023.11.001 Abstract （209）      PDF （8311KB）（1094）       The early symptoms of periodontitis are not obvious, while it always accompanied by severe alveolar ridge defects, tooth drifting, flaring, and even tooth loss in advanced stage. It leads to a heavy burden on the country, society, and patients themselves with high prevalence. In 2018, consensus reports on the Classification of Periodontal and Peri-implant Diseases and Conditions were published by the American Academy of Periodontology (AAP) and European Federation of Periodontology (EFP), which divided periodontitis into four stages and three grades. Subsequently, the EFP has published S3-level clinical guidelines for the treatment of stage Ⅰ-Ⅲ and stage Ⅳ periodontitis. This article will discuss the clinical diagnosis and treatment practice of severe periodontitis based on the 2018 Classification with a case of periodontitis (stage Ⅳ, grade C). Reference | Related Articles | Metrics

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Application Progress of Artificial Intelligence in Orthodontic Diagnosis, Treatment, and Soft Tissue Prediction LIU Jiayi, ZHOU Yanheng Journal of Oral Science Research    2023, 39 (10): 862-865.   DOI: 10.13701/j.cnki.kqyxyj.2023.10.002 Abstract （302）      PDF （825KB）（694）       In recent years, the application of artificial intelligence in the field of orthodontics is increasing, and many artificial intelligence models are applied to orthodontic diagnosis, treatment planning, prognosis prediction, etc. The research shows that the application of artificial intelligence in orthodontics can improve the efficiency of diagnosis and treatment with high accuracy, but there are also problems such as insufficient data, single sample source, poor interpretability of artificial intelligence model, etc. This review intends to provide an overview of the effectiveness of artificial intelligence models used in orthodontic diagnosis, treatment planning, and facial profile prediction after orthodontic treatment or orthognathic surgery, so as to comprehensively understand the status of artificial intelligence in orthodontics and provide reference for relevant research and clinical application. Reference | Related Articles | Metrics

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Transcriptome Sequencing Screened Differentially Expressed Genes in Leuk-1 Cells under Paeoniflorin Condition XIAO Lijun, CHEN Qianming, WU Yuqi, YANG Jiantang Journal of Oral Science Research    2023, 39 (6): 527-533.   DOI: 10.13701/j.cnki.kqyxyj.2023.06.012 Abstract （118）      PDF （1228KB）（671）       Objective: To analyze the gene expression of Leuk-1 cells regulated by paeoniflorin based on transcriptome sequencing, to excavate and analyze key genes, to study the mechanism of paeoniflorin on Leuk-1 cells, and to explore its medicinal value. Methods: Transcriptome analyze were carried out on Leuk-1 cells in zero, low (5 μmol/L), and high (10 μmol/L) concentration groups. A series of different expression genes (DEGs) were screened, and the gene function and pathways of DEGs were annotated by Gene Ontology enrichment and KEGG enrichment analysis. Results: Among 1212 DEGs identified in Leuk-1 cells under the influence of paeoniflorin, Gene Ontology enrichment analysis revealed significant enrichment in immune response, humoral immune response, cytokine-mediated signaling pathway, 2’-5’-oligoadenylate synthetase activity, serine-type endopeptidase activity, extracellular space, extracellular region, endoplasmic reticulum, and other pathways. KEGG pathways enrichment indicated that DEGs were significantly enriched in Herpes simplex virus 1 infection, pathways in cancer, cytokine-cytokine receptor interaction, human papillomavirus infection, and other pathways. RT-qPCR examination of DEGs confirmed that accuracy of RNA-seq analysis. The role of paeoniflorin was mainly reflected in antiviral infection, tumor inhibition, protection of epithelial integrity, and immune regulation. Conclusion: The results of this experiment provided a reference to further study the molecular mechanism and provided clues to explore the prevention and treatment of oral mucosal diseases. Reference | Related Articles | Metrics

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Advancements in Application of Copper Death in the Diagnosis and Treatment of Oral Cancer WANG Chenchen, XU Yu Journal of Oral Science Research    2023, 39 (9): 771-774.   DOI: 10.13701/j.cnki.kqyxyj.2023.09.002 Abstract （187）      PDF （812KB）（637）       Oral cancer is the sixth most frequently occurring type of cancer in the world, whose incidence is on the rise in China. How to alleviate patients'pain and improve their prognosis through effective treatment is an issue worthy of our research and discussion. Recent research has identified a copper-dependent form of cell death known as 'cuprotosis'. Copper binds directly to the lipid acylated fraction involved in mitochondrial respiration, contributing to the aggregation of lipidated proteins and the reduction of iron-sulphur cluster proteins, resulting in a proteotoxic response that leads to cell death. Because abnormalities of copper homeostasis in the body can affect the growth of tumour cells, the efficacy of copper homeostasis in the diagnosis and treatment of malignancies has attracted much attention in recent years. This paper briefly describes three copper-mediated anti-tumour mechanisms and a variety of novel copper complexes involved in solving clinical problems in oral malignancies. We hope that this will provide a reference for the clinical management of oral cancer. Reference | Related Articles | Metrics

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Advances of Pulpotomy in Permanent Teeth: from Fundamental to Clinical Application LANG Xuelian, HU Tao Journal of Oral Science Research    2023, 39 (10): 866-870.   DOI: 10.13701/j.cnki.kqyxyj.2023.10.003 Abstract （221）      PDF （849KB）（620）       Pulpotomy is the routine of vital pulp therapy. Based on the theory of minimally invasive endodontics (MIE), the physiological function of soft and hard tissues can be preserved to the maximum extent. In order to ensure the clinical prognosis of pulpotomy, this article reviewed the basic and clinical literature of pulpotomy in recent years and summarized the clinical operating procedures, with hope to provide some references for future clinical practice and research. Reference | Related Articles | Metrics

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The Challenges, Key Factors and Progress of Periodontal Regeneration Therapy YAN Fuhua, YUAN Zhiyao Journal of Oral Science Research    2023, 39 (6): 473-478.   DOI: 10.13701/j.cnki.kqyxyj.2023.06.001 Abstract （440）      PDF （1036KB）（599）       The ultimate goal of periodontal disease treatment is to achieve periodontal tissue regeneration. However, it is difficult to achieve a true periodontal regeneration. Increasing the clinical predictability of periodontal regeneration and restoring the structure and function of cementum-periodontal ligament-alveolar bone complex remain great challenges. This article provides a brief overview of the challenges faced in periodontal regeneration treatment and explores the possible solutions based on the key elements of periodontal regeneration and recent research progress. Reference | Related Articles | Metrics

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Research Progress and Clinical Significance of Implant Neck Design. ZHOU Yanmin, WANG Hanchi Journal of Oral Science Research    2022, 38 (11): 1005-1009.   DOI: 10.13701/j.cnki.kqyxyj.2022.11.001 Abstract （273）      PDF （915KB）（551）       The design and development of dental implants lead the progress of implant technology and further influence the clinical treatment outcomes. The different neck structure design of implant is closely related to the stability of marginal bone, the health of peri-implant tissue, and the aesthetic effect, which is the key factor to determine the survival rate and success rate of implant in clinical treatment. This review summarizes the development process and suitable conditions of dental implant neck from both macroscopic aspect, such as platform design, diameter and thread, and microscopic aspect, such as surface roughness, in order to assist clinician to choose appropriate implant and provide personalized plan according to the patients' condition in the process of diagnosis and treatment. Reference | Related Articles | Metrics

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Research Progress on Relationship between Periodontitis and Oral as well as Gut Microbiota CHEN Qi, GONG Ting Journal of Oral Science Research    2023, 39 (2): 109-112.   DOI: 10.13701/j.cnki.kqyxyj.2023.02.004 Abstract （355）      PDF （776KB）（525）       The gut microbiota is the largest microbial community in the human body. Recent studies have shown that the gut microbiota is closely related to the health of the whole body. The gut dysbiosis plays an important role in obesity, heart disease, autism, diabetes, et al. Periodontitis is one of the most common oral diseases, manifested as alveolar bone loss, tooth loosening, etc. Recent studies have shown that periodontitis can affect the gut microbiota. This article discusses the effect of periodontitis on the gut microbiota, possible routes, and factors of oral microbiota to influence gut microbiota, in order to provide reference for exploring the correlation between periodontitis and gut microbiota. Reference | Related Articles | Metrics

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Research Progress on Role of Nerve in Repair of Damaged Dental Pulp WANG Chunmeng, ZHANG Qi Journal of Oral Science Research    2022, 38 (12): 1110-1114.   DOI: 10.13701/j.cnki.kqyxyj.2022.12.002 Abstract （257）      PDF （859KB）（515）       The defense and self-repair function of pulp is the biological basis of damaged pulp repair and vital pulp therapy. As an important part of pulp tissue, nerve may play a role as the initiating factor after pulp injury. Pulp injury not only results in the changes of nerve distribution, structure, and signal transduction, but also affects other tissues and cells through related bioactive molecules. This article summarizes and discusses the role of nerve in pulp injury repair in recent years, with aid to provide reference and theoretical guidance for clinical treatment of vital pulp therapy. Reference | Related Articles | Metrics

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Extraction of Fractured Root in the Left Mandibular Canal: A Case Report ZHU Tianshuang, CAI Yu Journal of Oral Science Research    2022, 38 (11): 1098-1100.   DOI: 10.13701/j.cnki.kqyxyj.2022.11.020 Abstract （207）      PDF （2024KB）（499）       Root fracture often occurs during extraction of impacted mandibular third molars. The fractured root is difficult to be removed, especially in the mandibular canal, and even be pushed to the deeper place, which might lead to or aggravate the inferior alveolar nerve damage. This paper reported a case to remove the fractured root of impacted mandibular third molars, in the mandibular canal. Reference | Related Articles | Metrics

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Clinical Study of Keratinized Gingiva Augmentation in Maintaining Implant Stability with Chronic Periodontitis LU Jie, XU Yan, ZOU Chenyang Journal of Oral Science Research    2023, 39 (6): 510-514.   DOI: 10.13701/j.cnki.kqyxyj.2023.06.009 Abstract （129）      PDF （3607KB）（489）       Objective: To evaluate the clinical effect of apically positioned flap combined with free gingival graft on the reconstruction of implant keratinized gingiva in patients with chronic periodontitis. Methods: Thirty chronic periodontitis patients with insufficient keratinized gingiva around implants were selected and randomly divided into FGG group and control group, with 19 implants in each group. The clinical parameters, including keratinized tissue width (KTW), peri-implant probing depth (PPD), gingival index (GI), modified plaque index (mPI), mucosal recession (MR), and marginal bone loss (MBL) were compared between two groups at baseline, 3 months, and 6 months after treatment. Results: During the period, the implant function of two groups was good, and some measurement indicators (KTW, GI, mPI, GR, MBL) in the FGG group were improved compared with the baseline ( P<0.05). After 6 months of follow-up, the conditions of peri-implant tissues (KTW, GI, PI, GR) in the FGG group were significantly improved compared with those in the control group ( P<0.05). Conclusion: APF combined with FGG is a practical method to reconstruct the keratinized gingiva of implants in patients with periodontitis. It can maintain the health and stabilize the bone level around the implant in short term. Reference | Related Articles | Metrics

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Research Progress on Relationship and Mechanism between Sleep Disorder and Periodontitis YE Gang, SHAN Lihua Journal of Oral Science Research    2023, 39 (2): 105-108.   DOI: 10.13701/j.cnki.kqyxyj.2023.02.003 Abstract （274）      PDF （796KB）（469）       Periodontitis is a common disease of oral cavity. In recent years, many studies have shown that sleep disorder is associated with periodontitis, and its mechanism may involve psychological stress, circadian rhythm disorder, systemic inflammation, immune suppression, and systemic fatigue, which provides a new perspective for the prevention and treatment of periodontitis. This article reviews the relationship and mechanism between sleep disturbance and periodontitis. Reference | Related Articles | Metrics

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Progress in Pain Management after Extraction of Impacted Mandibular Third Molars ZHOU Shizheng, ZOU Haixiao Journal of Oral Science Research    2024, 40 (2): 103-107.   DOI: 10.13701/j.cnki.kqyxyj.2024.02.002 Abstract （156）      PDF （806KB）（446）       In order to relieve the postoperative pain and improve the quality of life, relevant experts recommend systematic management of tooth extraction pain, so as to improve the prognosis of patients. This review aimed to introduce the mechanism and types of pain and the intervention of pain after mandibular third molars extraction, with a view to provide guidance for the clinical management of pain in mandibular impacted third molars extraction. Reference | Related Articles | Metrics

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Application of 3D Printed Individual Titanium Mesh in Bone Augmentation in Dental Implant Region WANG Zhiying Journal of Oral Science Research    2023, 39 (5): 383-387.   DOI: 10.13701/j.cnki.kqyxyj.2023.05.001 Abstract （329）      PDF （1188KB）（432）       As a shield membrane of GBR, 3D printed individual titanium mesh(3D-PITM) has the advantage of good space maintaining for bone reconstruction and predictable horizontal and vertical bone augmentation. This article reviews the application of 3D-PITM by discussing thickness, porosity, osteogenic property, design and fabrication, surgical method, complications, comparision of contour of postoperative new bone and pre-operative bone expected, and the influence factors, prevention and treatment of titanium mesh exposure. Reference | Related Articles | Metrics

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Treatment Approaches for Sinus Lift in the Presence of Maxillary Sinus Cyst LIU Zhonghao, ZHOU Wenjuan Journal of Oral Science Research    2023, 39 (4): 289-294.   DOI: 10.13701/j.cnki.kqyxyj.2023.04.001 Abstract （278）      PDF （8379KB）（430）       As an evidence-based technique, maxillary sinus floor elevation can augment the available bone height for implant placement via elevating the sinus mucosa to provide bone regeneration space. This technique can be divided into lateral window technique and trans-crestal technique, which can be influenced by different risk factors such as membrane thickness, the sinus anatomy, and sinus lesions. Among all the risk factors, sinus mucosa cysts may increase the level of treatment difficulty and the surgery complications. The treatment option for such lesion during maxillary sinus floor elevation is still controversial, this paper summarized different treatment approaches to place implants in patients with sinus mucosa cysts when sinus floor elevation is needed. Reference | Related Articles | Metrics

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Study and Application of Vital Pulp Therapy in Mature Permanent Teeth LI Zeqi, LIU Qingmei Journal of Oral Science Research    2023, 39 (4): 300-303.   DOI: 10.13701/j.cnki.kqyxyj.2023.04.003 Abstract （242）      PDF （1593KB）（425）       Maintaining vitality of the pulp is of great significance to the long-term preservation of mature permanent teeth. In recent years, supported by the studies of pulp biology, minimally invasive treatment of pulp and preservation of remaining healthy pulp have become the new target employed for mature permanent teeth with pulpitis. The primary aim of this review was to elaborate the research and application of vital pulp therapy (VPT) in mature permanent teeth in terms of classification, treatment, prognosis, and application of laser. Reference | Related Articles | Metrics

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Early Screening of Periodontal Disease Based on Deep Learning of Intra Oral Digital Image ZHU Hongbiao, LIU Qiangdong, ZENG Ziqiang, LOU Weiming, DAI Fang, WU Jingting, DENG Tian, DENG Libin, SONG Li Journal of Oral Science Research    2022, 38 (11): 1092-1095.   DOI: 10.13701/j.cnki.kqyxyj.2022.11.018 Abstract （277）      PDF （1052KB）（423）       Objective: To construct an artificial intelligence (AI) early screening model of periodontal disease based on convolutional neural network (CNN) deep learning technology, and to assist non-periodontal doctors in early screening of periodontal disease. Methods: The oral digital photos and clinical data of periodontal non-healthy people and periodontal healthy people were collected from the Second Affiliated Hospital of Nanchang University. Vgg-16 was used to train and test intra oral digital images. Three training models, i.e. nine grid mouth, orthotopic occlusal, and orthotopic occlusal excluding invalid background, were established. Results: A total of 3869 oral digital images of 578 subjects were collected, including 2230 periodontal healthy images and 1639 periodontal unhealthy images. Vgg-16 was used to establish three kinds of training set models. The accuracy of prediction of digital image in nine grid mouth, digital image in orthotopic occlusal mouth, and digital image in orthotopic occlusal mouth excluding invalid background were 66.62%, 64.66%, and 77.44%, respectively. AUC values were 0.651, 0.767, and 0.784, respectively. Conclusion: The VGG-16 model constructed in this study can effectively assist non-periodontal doctors in early screening of periodontal disease through intra-oral digital image recognition. Reference | Related Articles | Metrics

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Advance in Effects of Deep Margin Elevation on Periodontal Tissue ZHANG Jingqiu, HE Shuqi Journal of Oral Science Research    2023, 39 (4): 295-299.   DOI: 10.13701/j.cnki.kqyxyj.2023.04.002 Abstract （500）      PDF （1328KB）（422）       Subgingival dental defects are mainly caused by crown fracture and caries. Traditional restoration methods have poor prognosis due to many limitations. With the development of digital technology, adhesive materials, and the concept of minimally invasive restoration, deep margin elevation (DME), as a minimally invasive method for restoring subgingival tooth defects, has got more attention by prosthodontists for its high efficiency and convenience. To introduce the effect of DME on periodontal tissue, this review summarizes the research progress of material selection, postoperative marginal integrity, and biological width invasion. Reference | Related Articles | Metrics

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Minimally Invasive Aesthetic Restoration of Maxillary Anterior Teeth Assisted by Digital Technique: A Case Report JIANG Zhongwei, ZHOU Hongli, ZHANG Fan, CAI Xinjie Journal of Oral Science Research    2023, 39 (9): 848-851.   DOI: 10.13701/j.cnki.kqyxyj.2023.09.017 Abstract （138）      PDF （5751KB）（414）       A case of aesthetic defect of maxillary anterior teeth with altered passive eruption and diastema is performed periodontal surgery and veneer restoration assisted by digital technique, who finally achieves satisfactory treatment results. It is hoped that this case can be used as a reference for the digital treatment and multidisciplinary joint treatment of aesthetic defect cases in dental clinics. Reference | Related Articles | Metrics

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Potential and Challenges of Generative AI in Oral Medicine SU Liwen, WU Yang Journal of Oral Science Research    2024, 40 (1): 11-17.   DOI: 10.13701/j.cnki.kqyxyj.2024.01.003 Abstract （296）      PDF （998KB）（396）       As an essential branch of artificial intelligence (AI), generative AI has made significant progress in various domains in recent years. In the field of medicine, generative AI is also believed to hold tremendous potential for application. However, with the continuous development of this technology, it becomes imperative to address the ethical challenges and risks associated with it. This paper aims to explore generative AI, particularly the technology based on large language models (LLM), and provide valuable insights for further harnessing its potential in oral medicine research, clinical practice, and education. Reference | Related Articles | Metrics