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    Research Progress on Construction of Dynamic 3D Finite Element Model of Temporomandibular Joint
    LUO Liangyu, LIU Jun
    Journal of Oral Science Research    2022, 38 (8): 715-717.   DOI: 10.13701/j.cnki.kqyxyj.2022.08.003
    Abstract1244)      PDF (765KB)(1842)      
    The healthy temporomandibular joint (TMJ) is of vital importance to basic physiological functions such as mastication, swallowing, and speech. Temporomandibular joint disorders are possibly related to abnormal stress distribution in the TMJ. However, it is not feasible to directly measure the complex stress and strain distribution patterns in the TMJ by conventional measurements. Dynamic three-dimensional finite element analysis has become the main method to study the biomechanics of TMJ due to its accurate and non-invasive nature. However, there are significant differences in the geometric similarity and degree of mechanical simulation between different modelling methods. In this paper, the geometric model construction, material properties, contact relationship, and the kinematic loading of TMJ are reviewed.
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    Clinical Application of Dynamic Navigation in Acurate Dental Implant Placement
    FENG Dajun, XU Peng, SUN Yunfeng
    Journal of Oral Science Research    2021, 37 (7): 617-621.   DOI: 10.13701/j.cnki.kqyxyj.2021.07.009
    Abstract412)      PDF (4645KB)(1572)      
    Objective: To preliminarily evaluate the precision of guidance by computer dynamic navigation in dental implant placement. Methods: Seventeen patients (25 implants) were selected as the experimental group and implanted under the guidance of computer dynamic navigation. Eighteen patients (25 implants) who received freehand dental implant placement were selected as the control group. The entry position and angle of the planned implantation and actual implantation were measured, respectively. The deviation value was calculated for comparison. Results: The average deviation values of lingual(buccal)-tongue(palate) and proximal-distal directions in the experimental group were 0.210 mm and 0.318 mm, respectively, and average deviation of angle was 3°. The average deviation values in the control group were 0.339 mm and 1.059 mm, respectively, and average deviation of angle was 6.12°. The implantation accuracy of experimental group was better than that of control group ( P<0.001). Conclusion: The dynamic navigation system can significantly improve the precision of dental implant placement.
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    Influence of Circadian Disruption on Dentin Development in Mice
    LI Ruiqi, HUANG Wushuang, LI Shiyu, ZHENG Xueqing, LIU Nianke, SONG Yaling
    Journal of Oral Science Research    2022, 38 (8): 731-735.   DOI: 10.13701/j.cnki.kqyxyj.2022.08.007
    Abstract459)      PDF (1689KB)(547)      
    Objective: To investigate the effect of circadian disruption during dentin formation. Methods: The model of environmental circadian disruption was constructed in mice and immunohistochemistry (IHC) was employed to detect the expression of BMAL1, PER2, and DSPP in molar germs in offspring of pregnant mice. Mouse dental papilla cells (mDPCs) were separated from Kunming mice at postnatal day 1 (PN1). After synchronization, the cells were cultured for 48h and harvested every 6h. qRT-PCR was used to explore the expression of Bmal1 and Per2. Scanning electron microscope (SEM) was used to compare the structure of dentinal tubules in the sagittal plane of incisor and molar in control and disturbance group. Energy-dispersive X-ray spectroscopy (EDS) was performed for surface elements analysis of mandibular incisors. The mineral density of dentin in both groups was compared and analyzed. Results: The expression of BMAL1, PER2, and DSPP decreased in the mandibular first molar germs of circadian rhythm disturbance group compared with the control group. Moreover, during 48h period, Bmal1 and Per2 exhibited a rhythmic profile in synchronized mouse dental papilla cells. The element weight percent of Ca and the value of the Ca/P ratio were reduced in disturbance group compared with those in the control group. The results of SEM and mineral density of dentin exhibited no obvious abnormalities. Conclusion: Circadian rhythm might involve in regulating dentin development.
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    Experimental Study and Clinical Observation of Hyaluronic Acid Gel Combined with Nd:YAG Laser on Sensitivity of Tooth Root of Elderly Patients with Periodontitis
    ZHOU Yue, SHEN Yuqin
    Journal of Oral Science Research    2021, 37 (1): 39-42.   DOI: 10.13701/j.cnki.kqyxyj.2021.01.009
    Abstract460)      PDF (1465KB)(779)      
    Objective: To observe and evaluate the clinical effect of hyaluronic acid gel combined with Nd:YAG laser in the treatment of tooth root sensitivity complications after periodontal initial therapy in elderly patients. Methods: 24 complete caries-free premolars of elderly patients due to chronic periodontitis were selected, and randomly divided into 4 groups. The tooth roots were treated by using normal saline, hyaluronic acid gel, Nd: YAG laser, and hyaluronic acid gel combined with Nd: YAG laser, respectively. The morphology of all 24 specimens was observed under scanning electron microscope. 60 elderly patients with tooth root sensitivity complications after periodontal initial therapy were randomly divided into 3 groups, which were hyaluronic acid gel group (20 cases, 66 teeth), Nd: YAG laser group (20 cases, 81 teeth), and the combined group (20 cases, 102 teeth). The hyaluronic acid gel group was treated with hyaluronic acid gel alone, the Nd: YAG laser group was treated with Nd:YAG laser irradiation, and the combined group was treated with hyaluronic acid gel combined with the laster irradiation. The effects were evaluated by Schiff cold air sensitivity index. Results: Scanning electron microscopy showed that hyaluronic acid gel, Nd:YAG laser irradiation, and hyaluronic acid gel combined with Nd:YAG laser irradiation can seal the dentin tubules, but hyaluronic acid gel combined with Nd:YAG laser had the best effect. The clinical observation results showed that the effective rates of hyaluronic acid gel group, the Nd:YAG laser group, and the combined group were 69.70%, 83.95%, and 93.13% ( P<0.05). Conclusion: Hyaluronic acid gel combined with Nd:YAG laser irradiation has better clinical effects in the treatment of tooth root sensitivity complications after periodontal initial therapy in elderly patients.
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    Clinical Features and Relapse Prevention of Epulis: A Retrospective Study of 234 Cases
    KE Xiaojing, JIN Ou, YAN Fuhua, LI Yanfen, LI Houxuan
    Journal of Oral Science Research    2022, 38 (5): 429-435.   DOI: 10.13701/j.cnki.kqyxyj.2022.05.009
    Abstract823)      PDF (5449KB)(1305)      
    Objective: To analyze clinical features of epulis and provide a reference for delving into the biological behavior and prevention of relapse of epulis. Methods: Patients diagnosed as epulis through outpatient and postoperative pathology at the Department of Periodontology, Nanjing Stomatological Hospital, Medical School of Nanjing University from 2018 to 2019 were retrospectively analyzed. Results: A total of 234 cases of epulides were included. The peak incidence of epulis fell in 21 to 30 years old, and the total ratio of males to females was about 1∶2.2. Female was more frequent in the group from 31 to 70 years ( P<0.05), yet there was no statistically difference in the proportion of male and female under the age of 30 ( P>0.05). Histopathological examination revealed fibrous epulis (121 cases, 51.71%), granuloma epulis (76 cases, 32.48%), vascular epulis (36 cases, 15.38%), and giant cell epulis (1 case, 0.43%). There was no significant difference in the distribution of the upper and lower jaws of epulis ( P>0.05), and the anterior teeth area was the common location ( P<0.001). In addition, epulis were mostly located on the buccal side (66.67%) and least in the edentulous area (1.28%). The size of epulis varied from 0.3 cm to 2.2 cm in diameter, most of which were distributed among the range of 0.6 cm to 1.5 cm (78.2%). Two cases had relapsed after periodontal system treatment in the short term, and the recurrence rate was 0.85%. Conclusion: Epulides are more prevalent in females and young patients(21 to 30 years old). The majority of epulides were located in the anterior region and on the buccal side. Perfect inflammation control and thorough surgical resection can effectively control the recurrence of epulis.
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    Local Tissue Necrosis of Hard Palate Mucosa Caused by Articaine Hydrochloride and Epinephrine Tartrate Injection: One Case Report
    LIN Yuhong, LI Xiaoning, SUN Yi, LIU Xue, LU Zhishan
    Journal of Oral Science Research    2021, 37 (5): 479-480.   DOI: 10.13701/j.cnki.kqyxyj.2021.05.020
    Abstract464)      PDF (1288KB)(765)      
    Articaine hydrochloride and epinephrine tartrate injection is a local anesthetic method widely used in oral clinic, and its adverse reactions occur sometimes. In this paper, a case of local tissue necrosis of hard palate mucosa caused by local infiltration anesthesia of articaine hydrochloride and epinephrine tartrate injection in the right maxillary second molar was reported
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    Antibacterial Effect of Injectable Hydrogel with Chlorhexidine on Enterococcus Faecalis and Biofilm in Vitro
    XU Laijun, YUAN He, LI Jiyao
    Journal of Oral Science Research    2022, 38 (1): 45-50.   DOI: 10.13701/j.cnki.kqyxyj.2022.01.010
    Abstract558)      PDF (4855KB)(1413)      
    Objective: To study the effect of chlorhexidine-loaded gellan gum hydrogel against Enterococcus faecalis and biofilm in vitro. Methods: The gellan gum containing hydroxyapatite was prepared by adding crosslinking agent (calcium ion), and chlorhexidine was effectively loaded. The effect of hydrogels against Enterococcus faecalis in vitro was evaluated by measuring bacterial growth curves and scanning electron microscopy, and their inhibiting the bacterial biofilms was observed by quantitative crystal violet staining and confocal laser scanning microscope. Results: As the concentration of chlorhexidine in the hydrogel increased, the antibacterial activity gradually increased. When the concentration of chlorhexidine was 50 μg/mL, it could significantly inhibit bacterial growth and biofilm formation. When the concentration was 250 μg/mL, it could show significant bactericidal effect. Conclusion: The gellan gum hydrogel loaded with chlorhexidine presented great effects on inhibiting the growth of Enterococcus faecalis and removing their biofilm. It might be a novel injectable biomaterial to disinfect root canals and promote the healing of refractory periapical periodontitis.
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    Clinical Practice of Preformed Crown on Children's First Permanent Molars
    TIAN Yuting, CHENG Li
    Journal of Oral Science Research    2021, 37 (1): 6-10.   DOI: 10.13701/j.cnki.kqyxyj.2021.01.002
    Abstract645)      PDF (4389KB)(2016)      
    On account of its special function and position, the first permanent molars play a very important role in oral health and even in general health. The diseases occurring in the first permanent molar, if not treated in time, may lead to serious tooth defects or even tooth extraction. At present, the management standard of severely damaged first permanent molars has not been described clearly in the literature, and the relevant researches on restorative techniques are limited. The purpose of this paper is to provide some references and ideas for relevant clinical decisions and future research directions, by means of expounding the importance of first permanent molars, analyzing the necessity and treatment status of restoration for tooth defect, and introducing the effect and clinical application of preformed metal crowns in children's first permanent molars.
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    Prediction of Potential Targets and Molecular Mechanisms of Compound Honeysuckle in Prevention and Treatment of Periodontitis Based on Network Pharmacology and Molecular Docking Technology
    XIANG Jing, CHEN Qihang, QIANG Xiaoye, WANG Shuxin, ZHANG Dejun
    Journal of Oral Science Research    2025, 41 (1): 26-34.   DOI: 10.13701/j.cnki.kqyxyj.2025.01.006
    Abstract1093)      PDF (5942KB)(1934)      
    Objective: To screen the potential active components and molecular mechanisms of Compound Honeysuckle by network pharmacology in preventing and treating periodontitis and to verify the inhibitory effect of compound honeysuckle on Porphyromonas gingivalis (Pg) through experimental validation. Methods: Active components and targets were screened using multiple databases combined with ADME and Lipinski's rules. A drug-active component-target network was constructed, and core targets were identified through the PPI network. GO and KEGG enrichment analyses were used to explore the functions and pathways of the targets. Molecular docking was used to validate the binding activity between active components and target proteins. The inhibitory effect of compound honeysuckle on Pg was determined using the broth microdilution method. Results: A total of 38 active components of compound honeysuckle were identified, with key targets including AKT serine/threonine kinase 1 (AKT 1), epidermal growth factor receptor erbB1 (EGFR),and heat shock protein 90 alpha family class A member 1 (HSP90AA1). KEGG analysis indicated that compound honeysuckle may exert its effects through the regulation of the phosphatidylinositol 3-kinase/Akt Pathway (PI3K-Akt), calcium signaling pathways, and cancer-related pathways. Molecular docking confirmed good binding affinity between key compounds and targets. In vitro experiments showed that the MIC and MBC of compound honeysuckle against Pg were both 5.469 mg/mL. Conclusion: Compound honeysuckle shows potential in preventing and treating periodontitis through the modulation of multiple targets and signaling pathways, providing a theoretical basis for further research and clinical applications.
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    A Case Report of Initial Periodontal Therapy for Generalized Severe Periodontitis (Stage Ⅱ Grade B)
    WU Jing, NA Xin, PENG Simin, CAO Zhengguo, WANG Xiaoxuan
    Journal of Oral Science Research    2025, 41 (3): 260-264.   DOI: 10.13701/j.cnki.kqyxyj.2025.03.016
    Abstract390)      PDF (5060KB)(953)      
    This article systematically documents the complete treatment process of a case with generalized stage Ⅱ grade B periodontitis, following the S3-level clinical practice guidelines of the European Federation of Periodontology (EFP). By demonstrating the synergistic effects of initial periodontal therapy and supportive periodontal care (SPC), we aim to enhance dental practitioners' understanding of standardized periodontal treatment. Clinical practice has proven that standardized initial periodontal therapy combined with long-term SPC monitoring can effectively control disease progression, maintain treatment outcomes, and reduce recurrence risk. This systematic treatment approach provides a reliable clinical solution for reducing the burden of periodontal diseases.
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    Journal of Oral Science Research    2015, 31 (6): 549-554.  
    Abstract255)      PDF (1396KB)(1594)      
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    Influence of Ferrule Heights and Crown-to-root Ratios on Fracture Resistance of Residual Roots Restored with Different Post-and-core Systems in Vitro
    CHEN Yuxin, LI Yingmei, DU Chen, XU Zhiming, MENG Qingfei, MENG Jian
    Journal of Oral Science Research    2022, 38 (12): 1161-1166.   DOI: 10.13701/j.cnki.kqyxyj.2022.12.012
    Abstract486)      PDF (1458KB)(788)      
    Objective: To investigate the effect of different ferrule heights and crown-to-root ratios on the fracture resistance of premolar residual roots restored with cast or fiber post-and-core systems. Methods: Eighty sound mandibular first premolars with completely single root canal were selected, and the crowns were cut from 2.0 mm above the buccal cemento-enamel junction. The horizontal residual root models were carried out after root canal treatment. All 80 roots were randomly divided into groups A and B, and each group was divided into five subgroups, named as subgroups A0 to A4 and B0 to B4, respectively, with 8 roots each. The roots in group A were restored with prefabricated fiber post and core system, with no ferrule designs in subgroup A0. A1-A4 subgroups were designed with the ferrule height varying from 1.0 to 4.0 mm, respectively in the cervical roots by simulated surgical crown-lengthening methods. The roots in group B were given cast post and core restoration, and the ferrule designs in subgroups B0-B4 were the same as those in group A. All samples were restored with metal crowns and the teeth were embedded in an acrylic resin block to the height from the apical foramen to 2.0 mm below the crown margin. The clinical crown-to-root ratios of all subgroups were calculated as 0.62(A0, B0), 0.75(A1, B1), 0.91(A2, B2), 1.10(A3, B3), and 1.33(A4, B4), respectively. The specimen was placed on the universal mechanical machine and loaded to fracture at 135° to its long axis at a speed of 1.0 mm/min. The maximum loading values and fracture modes were recorded and analyzed statistically. Results: Mean fracture loads (kN) for subgroups A0 to A4 and B0 to B4 were as follows: 0.54 (0.09), 1.03 (0.11), 1.06 (0.17), 0.85 (0.11), 0.57 (0.10), 0.55 (0.09), 0.88 (0.13), 1.08 (0.17), 1.05 (0.18), and 0.49 (0.09). "Ferrule/crown-to-root ratio" could significantly affect the fracture resistance of residual roots ( P<0.05) and there was no significant difference for the effect of "post material" ( P>0.05), but there was a synergistic effect between two factors ( P<0.05). According to the cox linear logistic regression, when the loading fracture reached the maximum, the ferrule length and crown-to-root ratio in group A were 1.92 mm and 0.90, while those in group B were 2.07 mm and 0.92, respectively. Conclusion: When a certain height of ferrule is prepared and cast or fiber post system is restored for the residual root, the clinical crown-to-root ratio of the tooth after restoration should be kept within 0.90 to 0.92, so as to improve the fracture resistance of the tooth.
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    Effect of Mucosal Thickness and Implant Depth on Crestal Bone Change of Implants
    ZHANG Bo, RUI Yuxin
    Journal of Oral Science Research    2023, 39 (2): 141-144.   DOI: 10.13701/j.cnki.kqyxyj.2023.02.010
    Abstract461)      PDF (1538KB)(801)      
    Objective: To explore the effect of different implantation depths and gingival thicknesses on bone remodeling around implants. Methods: From January 2018 to June 2020, 78 patients who received single posterior implantation in the Implant Center of Taiyuan Hamony Long Stomatological Hospital were selected. A total of 96 platform-switching implants were implanted. They were divided into two groups according to the thickness of mucosa: thin gingiva group (< 3 mm) and thick gingiva group (≥ 3 mm). Forty-six implants in thin gingiva group were implanted 1.5 mm below the bone level, 50 implants in the thick gingival group were implanted aligning with the bone level. Digital periapical films were taken immediately after implantation and 6 months and 12 months after prostheses delivered. The changes of bone level in the two groups were measured, respectively. Results: There was no significant difference in bone resorption between thin gingiva group and thick gingiva group 6 and 12 months after prostheses delivered ( P>0.05). There was no thread exposure in thin gingiva group. Conclusion: The bone level of the implant can be maintained by placing the platform-switching implants into a suitable position under the bone level so as to make up for the lack of soft tissue thickness.
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    Application Progress of Artificial Intelligence in Orthodontic Diagnosis, Treatment, and Soft Tissue Prediction
    LIU Jiayi, ZHOU Yanheng
    Journal of Oral Science Research    2023, 39 (10): 862-865.   DOI: 10.13701/j.cnki.kqyxyj.2023.10.002
    Abstract786)      PDF (825KB)(2477)      
    In recent years, the application of artificial intelligence in the field of orthodontics is increasing, and many artificial intelligence models are applied to orthodontic diagnosis, treatment planning, prognosis prediction, etc. The research shows that the application of artificial intelligence in orthodontics can improve the efficiency of diagnosis and treatment with high accuracy, but there are also problems such as insufficient data, single sample source, poor interpretability of artificial intelligence model, etc. This review intends to provide an overview of the effectiveness of artificial intelligence models used in orthodontic diagnosis, treatment planning, and facial profile prediction after orthodontic treatment or orthognathic surgery, so as to comprehensively understand the status of artificial intelligence in orthodontics and provide reference for relevant research and clinical application.
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    Clinical Diagnosis and Treatment of Edentulous Implant Restoration with Digital Clinical Workflow
    CHEN Jiang, Zhang Sihui
    Journal of Oral Science Research    2020, 36 (3): 193-198.   DOI: 10.13701/j.cnki.kqyxyj.2020.03.001
    Abstract572)      PDF (1279KB)(1242)      
    The wide application of digital technology in the field of stomatology has solved many problems exist in traditional implant restoration for edentulous patients. However, a wide variety of digital equipment and technology still need to be integrated. This article discussed the traditional and digital workflow of implant restoration for edentulous patients and its characteristics. And in order to standardize clinical practice, the digital clinical diagnosis and treatment workflow of implant restoration for edentulous patients was proposed.
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    Application of Multi-task Collaborative Intervention in Older Adults with Oral Frailty
    LIU Ge, LIU Chang
    Journal of Oral Science Research    2025, 41 (9): 737-742.   DOI: 10.13701/j.cnki.kqyxyj.2025.09.001
    Abstract209)      PDF (841KB)(271)      
    Oral frailty is an emerging health issue that has attracted widespread attention, but most studies in China have focused on conceptualization, development of screening tools, and epidemiological characterization, while systematic research on its pathological mechanisms and intervention strategies is still insufficient. Although a single oral function training, exercise, or nutritional intervention can partially improve oral frailty in older adults, recent evidence suggests that a collaborative intervention strategy based on multi-systemic interactions has more significant clinical advantages. In this paper, we systematically analyze the pathophysiological basis of oral frailty, elucidate the mechanism of multidimensional synergistic interventions (combined oral-exercise-nutritional interventions), and comparatively analyze the clinical effects of different intervention modes, with the aim of providing evidence-based evidence for the construction of a comprehensive management program of oral health in older adults.
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    Challenges and Countermeasures of Pulp Regeneration Technology in Mature Permanent Teeth
    HUANG Mengyu, LIU Shengbo
    Journal of Oral Science Research    2022, 38 (10): 922-925.   DOI: 10.13701/j.cnki.kqyxyj.2022.10.004
    Abstract602)      PDF (792KB)(1010)      
    Pulp regeneration technology is becoming a research hot issue in recent years, and it is also a good alternative treatment for root canal treatment. The current researches on pulp regeneration mainly focused on immature permanent teeth. In fact, there are far more mature permanent teeth that require endodontic treatment than immature permanent teeth. Therefore, pulp regeneration has great application prospects for mature permanent teeth. Compared with immature permanent teeth, mature permanent teeth have difficulties such as fully developed apical foramen, diverse anatomical structures, and complex microenvironment, etc. It is difficult to achieve pulp regeneration. This article reviews the related researches in recent years and discusses the difficulties and coping solutions of mature permanent teeth in pulp regeneration, in order to provide reference for the future development of pulp regeneration technology in mature permanent teeth.
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    Research Progress on Mechanism of Macrophages Affecting Bone Formation
    NIE Zhangling, BAO Chongyun
    Journal of Oral Science Research    2021, 37 (11): 966-969.   DOI: 10.13701/j.cnki.kqyxyj.2021.11.002
    Abstract1067)      PDF (827KB)(1471)      
    Macrophages play a key role in bone formation, and their specific performance is regulated by multiple complex biological mechanisms. Specifically, certain signaling molecules secreted by macrophages, such as oncostatin M (OSM), prostaglandin E2 (PGE2), bone morphogenetic protein-2 (BMP-2), and tumor necrosis factor-α (TNF-α), have a key role in osteogenesis. In addition, polarized subtypes of macrophages also play a regulatory role at different stages of osteogenesis. This article reviews the research progress of the related mechanisms of macrophages influencing bone formation in recent years.
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    The S3 Level Clinical Diagnosis and Practice Guideline of Stage Ⅳ Severe Periodontitis Based on 2018 EFP/AAP Classification
    CAO Zhengguo, GAO Ya, ZENG Yu
    Journal of Oral Science Research    2023, 39 (11): 943-951.   DOI: 10.13701/j.cnki.kqyxyj.2023.11.001
    Abstract1007)      PDF (8311KB)(3849)      
    The early symptoms of periodontitis are not obvious, while it always accompanied by severe alveolar ridge defects, tooth drifting, flaring, and even tooth loss in advanced stage. It leads to a heavy burden on the country, society, and patients themselves with high prevalence. In 2018, consensus reports on the Classification of Periodontal and Peri-implant Diseases and Conditions were published by the American Academy of Periodontology (AAP) and European Federation of Periodontology (EFP), which divided periodontitis into four stages and three grades. Subsequently, the EFP has published S3-level clinical guidelines for the treatment of stage Ⅰ-Ⅲ and stage Ⅳ periodontitis. This article will discuss the clinical diagnosis and treatment practice of severe periodontitis based on the 2018 Classification with a case of periodontitis (stage Ⅳ, grade C).
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    The Challenges, Key Factors and Progress of Periodontal Regeneration Therapy
    YAN Fuhua, YUAN Zhiyao
    Journal of Oral Science Research    2023, 39 (6): 473-478.   DOI: 10.13701/j.cnki.kqyxyj.2023.06.001
    Abstract1116)      PDF (1036KB)(1562)      
    The ultimate goal of periodontal disease treatment is to achieve periodontal tissue regeneration. However, it is difficult to achieve a true periodontal regeneration. Increasing the clinical predictability of periodontal regeneration and restoring the structure and function of cementum-periodontal ligament-alveolar bone complex remain great challenges. This article provides a brief overview of the challenges faced in periodontal regeneration treatment and explores the possible solutions based on the key elements of periodontal regeneration and recent research progress.
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