Urine-derived Stem Cells and Their Potential Applications in Oral Maxillofacial Tissue Engineering and Regeneration

doi:10.13701/j.cnki.kqyxyj.2018.02.024

Abstract

Abstract: Urine-derived stem cells (USCs) are novel adult stem cells existing in urine which possesses highly expandability, self-renewal capacity, paracrine properties, and multi-differentiation potential. In tissue regeneration, as a new source of cells, the USCs have excellent feasibility and safety. Most importantly, the body has a substantial source of USCs, which can be harvested easily in a non-invasive manner, regardless of the age, sex, and health condition of patients. USCs have been used in preclinical animal models to repair or regenerate tissue, employing either trans-differentiation or paracrine effects to stimulate endogenous cells participating in tissue regeneration. The potential application of USCs in oral maxillofacial tissue regeneration is reviewed in this paper.

Key words: Urine-derived stem cells, Tissue engineering, Tooth regeneration

CLC Number:

QU Jiao-jiao, WANG Shuai, WU Jia-yuan. Urine-derived Stem Cells and Their Potential Applications in Oral Maxillofacial Tissue Engineering and Regeneration[J]. Journal of Oral Science Research, 2018, 34(2): 206-208.

References

[1] Zhang D, Wei G, Li P, et al. Urine-derived stem cells: A novel and versatile progenitor source for cell-based therapy and regenerative medicine [J]. Genes & Diseases, 2014, 1(1)∶8-17
[2] Bharadwaj S, Liu G, Shi Y, et al. Characterization of urine-derivedstem cells obtained from upper urinary tract for use in cell-basedurological tissue engineering [J]. Tissue Eng Part A, 2011, 17(15-16)∶2123-2132
[3] Chun SY, Kim HT, Lee JS, et al. Characterization of urine-derived cells from upper urinary tract in patients with bladder cancer [J]. Urology, 2012, 79(5)∶1186. e1-1186. e7
[4] Guan JJ, Niu X, Gong FX, et al. Biological characteristics of human-urine-derived stem cells: potential for cell-based therapy in neurology [J]. Tissue Engineering Part A, 2014, 20(13-14)∶1794-1806
[5] Schosserer M, Reynoso R, Wally V, et al. Urine is a novel source of autologous mesenchymal stem cells for patients with epidermolysis bullosa [J]. BMC research notes, 2015, 8(1)∶1
[6] Bharadwaj S, Liu G, Shi Y, et al. Multipotential differentiation of human urine‐derived stem cells: Potential for therapeutic applications in urology [J]. Stem cells, 2013, 31(9)∶1840-1856
[7] Atala A, Bauer SB, Soker S, et al. Tissue-engineered autologous bladders for patients needing cystoplasty [J]. The lancet, 2006, 367(9518)∶1241-1246
[8] Bharadwaj S, Liu GH, Wu S, et al. 172 In vivo skeletal myogenic differentiation of autologous urine-derived stem cells for potential application in treatment of urinary incontinence [J]. The Journal of Urology, 2011, 185(4)∶e72
[9] Liu G, Shantaram B, Atala A, et al. 203 Endothelial differentiation of human urine derived stem cells for urological tissue regeneration [J]. The Journal of Urology, 2012, 187(4)∶e85
[10] Liu G, Pareta R A, Wu R, et al. Skeletal myogenic differentiation of urine-derived stem cells and angiogenesis using microbeads loaded with growth factors [J]. Biomaterials, 2013, 34(4)∶1311-1326
[11] Wu S, Liu Y, Bharadwaj S, et al. Human urine-derived stem cells seeded in a modified 3D porous small intestinal submucosa scaffold for urethral tissue engineering [J]. Biomaterials, 2011, 32(5)∶1317-1326
[12] Lee JN, Chun SY, Lee HJ, et al. Human Urine-derived Stem Cells Seeded Surface Modified Composite Scaffold Grafts for Bladder Reconstruction in a Rat Model [J]. Journal of Korean medical science, 2015, 30(12)∶1754-1763
[13] Wu S, Wang Z, Bharadwaj S, et al. Implantation of autologous urine derived stem cells expressing vascular endothelial growth factor for potential use in genitourinary reconstruction [J]. The Journal of urology, 2011, 186(2)∶640-647
[14] Liu G, Bharadwaj S, Atala A, et al. Pd8-02 Enhance Myogensis And Innervation After Implantation Of Urine-Derived Stem Cells Expressing Vegf In Collagen-I Hydrogel [J]. The Journal of Urology, 2014, 191(4)∶e217
[15] Zhang SZ, Ma L X, Qian WJ, et al. Modeling Neurological Disease by Rapid Conversion of Human Urine Cells into Functional Neurons [J]. Stem cells international, 2015, 2016
[16] Wang L, Li X, Huang W, et al. TGFβ signalingregulates the choice between pluripotent and neural fates during reprogramming of human urine derived cells [J]. Scientific reports, 2016, 6
[17] Fu Y, Guan J, Guo S, et al. Human urine-derived stem cells in combination with polycaprolactone/gelatin nanofibrous membranes enhance wound healing by promoting angiogenesis [J]. Journal of translational medicine, 2014, 12(1)∶1
[18] Yuan H, Guan J, Zhang J, et al. Exosomes secreted by human urine‐derived stem cells accelerate skin wound healing by promotingangiogenesis in rat [J]. Cell biology international, 2016
[19] Guan J, Zhang J, Zhu Z, et al. Bone morphogenetic protein 2 gene transduction enhances the osteogenic potential of human urine-derived stem cells [J]. Stem cell research & therapy, 2015, 6(1)∶1
[20] Guan J, Zhang J, Guo S, et al. Human urine-derived stem cells can be induced into osteogenic lineage by silicate bioceramics via activation of the Wnt/β-catenin signaling pathway [J]. Biomaterials, 2015, 55∶1-11
[21] Cai J, Zhang Y, Liu P, et al. Generation of tooth-like structures from integration-free human urine induced pluripotent stem cells [J]. Cell Regeneration, 2013, 2(1)∶1
[22] Liu P, Zhang Y, Chen S, et al. Application of iPS cells in dental bioengineering and beyond [J]. Stem Cell Reviews and Reports, 2014, 10(5)∶663-670