Research Progress on Regulation of Macrophages Involvement in Periodontal Disease by Lactate/Lactation Modification

doi:10.13701/j.cnki.kqyxyj.2024.07.002

Abstract

Abstract: Lactate, as the end product of glycolysis, plays an important role in terms of energy sources, signaling molecules, and immune adjustment. Lactylation (Kla) is a newly discovered method to translate proteins based on lactate and lithium acid residues that are closely associated with a variety of inflammatory diseases. Peritoneal pathogens are the main cause of periodontitis (PD), which is an immune inflammation caused by the host's immune response. According to recent research, the increase of lactate content in periodontitis microenvironment leads to the increase of lactylation level, which can eventually slow down the spread of inflammation and help tissue repair by changing the polarization of macrophages and promoting the differentiation of bone cell. Therefore, this paper reviews the research progress of lactate/lactylation in regulating macrophage function and inflammatory diseases such as periodontitis in recent years, so as to provide reference for follow-up research and treatment of periodontitis.

Key words: lactate, lactylation, periodontitis, immune inflammation, post-translational modifications

WEI Yan, TIAN Ai. Research Progress on Regulation of Macrophages Involvement in Periodontal Disease by Lactate/Lactation Modification[J]. Journal of Oral Science Research, 2024, 40(7): 578-582.

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