Expression of  HMGB1 in Tongue Squamous Cell Carcinoma

Abstract

Abstract: Objective: To investigate the expression and biological significance of HMGB1 proteinin tissue specimens of tongue squamous cell carcinoma (TSCC), and study the correlation between HMGB1 and clinical features of the patients. Methods: The expression of HMGB1 protein was evaluated by immunohistochemical staining in 51 cases of TSCC specimens and further correlated with clinical pathologic parameters of the patients using statistical methods. Results: The positive rates of HMGB1 in TSCC tissues were 92.2%. The expression of HMGB1 was not significantly correlated with tumor histological differentiation, however it was closely correlated with lymph node metastasis (P<0.05) in TSCC. There were 81.2% high expression of HMGB1 in lymph node metastasis, while only 32.6 % in no metastasis cases. The Kaplan-Meier survival analysis showed that patients with strong expression of HMGB1 had poorer overall survival rate compared with that in patients with relatively low HMGB1 expression (P<0.05) . Conclusion: HMGB1 over-expression was closely associated with metastasis and poorer prognosis inpatients with TSCC.

Key words: High mobility group box -1 protein, Tongue squamous cell carcinoma, Lymph node metastasis

CLC Number:

R739.8

LI Jing, ZOU Tin-qian, WANG Wei, LI Chen-feng, ZENG Tao. Expression of HMGB1 in Tongue Squamous Cell Carcinoma[J]. Journal of Oral Science Research, 2015, 31(10): 1040-1042.

References

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Expression of HMGB1 in Tongue Squamous Cell Carcinoma

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