Progress in the Treatment of Nervous System Diseases with Dental Pulp Stem Cells

doi:10.13701/j.cnki.kqyxyj.2019.10.004

Abstract

Abstract: Dental pulp stem cells (DPSCs) are mesenchymal stem cells derived from neural crest. They have the biological characteristics of self-renewal ability and multi-lineage differentiation ability, and can differentiate into bone cells, adipose cells, and nerve cells under certain conditions. DPSCs secrete a variety of neurotrophic factors and express neurological markers. Many studies have confirmed that they have great potential in nerve repair and regeneration. In this paper, the characteristics of DPSCs, neurogenic differentiation, and repair of central nervous system and peripheral nerve system are reviewed.

Key words: dental pulp stem cells, neurogenic differentiation, nerve injury

ZHAO Zhe, ZHAO Hongyu. Progress in the Treatment of Nervous System Diseases with Dental Pulp Stem Cells[J]. Journal of Oral Science Research, 2019, 35(10): 925-927.

References

[1] Gronthos S, Mankani M, Brahim J, et al. Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo [J]. Proc Natl Acad Sci U S A, 2000, 97(25):13625-13630.
[2] Gronthos S, Brahim J, Li W, et al. Stem cell properties of human dental pulp stem cells [J]. J Dent Res, 2002, 8(81):531-535.
[3] Sakai K, Yamamoto A, Matsubara K, et al. Human dental pulp-derived stem cells promote locomotor recovery after complete transection of the rat spinal cord by multiple neuro-regenerative mechanisms [J]. J Clin Invest, 2012,122(1):80-90.
[4] Teixeira FG, Carvalho MM, Neves-Carvalho A, et al. Secretome of mesenchymal progenitors from the umbilical cord acts as modulator of neural/glial proliferation and differentiation [J]. Stem Cell Rev, 2015, 11(2):288-297.
[5] Mayo V, Sawatarib Y, Huanga CY, et al. Neural crest-derived dental stem cells-where we are and where we are going [J]. J Dent, 2014, 42(9):1043-1051.
[6] Mead B, Logan A, Berry M, et al. Intravitreally transplanted dental pulp stem cells promote neuroprotection and axon regeneration of retinal ganglion cells after optic nerve injury [J]. Invest Ophthalmol Vis Sci, 2013, 54(12):7544-7556.
[7] Mead B, Hill LJ, Blanch RJ, et al. Mesenchymal stromal cell-mediated neuroprotection and functional preservation of retinal ganglion cells in a rodent model of glaucoma [J]. Cytotherapy, 2016, 18(4):487-496.
[8] Ullah I, Subbarao RB, Kim E, et al. In vitro comparative analysis of human dental stem cells from a single donor and its neuronal differentiation potential evaluated by electrophysiology [J]. Life Sci, 2016, 154:39-51.
[9] Feng XM, Lu XH, Huang D, et al. 3D porous chitosan scaffolds suit survival and neural differentiation of dental pulp stem cells [J]. Cell Mol Neurobiol, 2014, 34(6):859-870.
[10] Gervois P, Struys T, Hilkens P, et al. Neurogenic maturation of human dental pulp stem cells following neurosphere generation induces morphological and electrophysiological characteristics of functional neurons [J]. Stem Cells Dev, 2015, 24(3):296-311.
[11] Gnanasegaran N, Govindasamy V, Kathirvaloo P, et al. Effects of cell cycle phases on the induction of dental pulp stem cells toward dopaminergic-like cells [J]. J Tissue Eng Regen Med, 2018, 12(2):e881-e893.
[12] Al-Zer H, Apel C, Heiland M, et al. Enrichment and Schwann cell differentiation of neural crest-derived dental pulp stem cells [J]. In Vivo, 2015,29(3):319-326.
[13] Radhakrishnan DM, Goyal V. Parkinson’s disease: A review [J].Neurol India, 2018,66 (Suppl) :S26-S35.
[14] 李政, 徐运. 帕金森病病因及发病机制的进展研究[J]. 国际神经病学神经外科学杂志,2014,41(4):345-348.
[15] Gnanasegaran N, Govindasamy V, Mani V, et al. Neuroimmunomodulatory properties of DPSCs in an in vitro model of Parkinson's disease [J]. IUBMB Life, 2017, 69(9):689-699.
[16] Gnanasegaran N, Govindasamy V, Simon C, et al. Effect of dental pulp stem cells in MPTP-induced old-aged mice model [J]. Eur J Clin Invest, 2017, 47(6):403-414.
[17] Kumar A, Singh A, Ekavali. A review on Alzheimer's disease pathophysiology and its management: an update [J]. Pharmacol Rep, 2015, 67(2):195-203.
[18] Wang F, Jia Y, Liu J, et al. Dental pulp stem cells promote regeneration of damaged neuron cells on the cellular model of Alzheimer's disease [J]. Cell Biol Int, 2017, 41(6):639-650.
[19] Ahmed Nel-M, Murakami M, Hirose Y, et al. Therapeutic potential of dental pulp stem cell secretome for Alzheimer's disease treatment: an in vitro study [J]. Stem Cells Int, 2016, 2016:8102478.
[20] Yang C, Li X, Sun L, et al. Potential of human dental stem cells in repairing the complete transection of rat spinal cord [J]. J Neural Eng, 2017,14(2):26005.
[21] Berry M, Ahmed Z, Lorber B, et al. Regeneration of axons in the visual system [J]. Restor Neurol Neurosci, 2008, 26(2-3):147-174.
[22] Bray AF, Cevallos RR, Gazarian K, et al. Human dental pulp stem cells respond to cues from the rat retina and differentiate to express the retinal neuronal marker rhodopsin [J]. Neurosci, 2014, 280:142-155.
[23] Carr MJ, Johnston AP. Schwann cells as drivers of tissue repair and regeneration [J]. Curr Opin Neurobiol, 2017,47:52-57.
[24] Yamamoto T, Osako Y, Ito M, et al. Trophic effects of dental pulp stem cells on Schwann cells in peripheral nerve regeneration [J]. Cell Transplantation, 2016, 25(1):183-193.
[25] Sanen K, Martens W, Georgiou M, et al. Engineered neural tissue with Schwann cell differentiated human dental pulp stem cells: potential for peripheral nerve repair [J]. J Tissue Eng Regen Med, 2017,11(12):3362-3372.