Research Progress on Effects of Platelet-rich Fibrin on Proliferation and Osteogenic Differentiation of Stem Cells.

doi:10.13701/j.cnki.kqyxyj.2019.06.005

Abstract

Abstract: Stem cells are the cells with high proliferation and multi-directional differentiation potential, which can be transformed into osteoblasts under specific induction conditions and promote bone tissue regeneration. Platelet-rich fibrin (PRF) is produced by the centrifugation of autologous venous blood, which is rich in a large number of growth factors, such as bone morphogenetic protein 2, platelet-derived growth factor, transforming growth factor, and insulin-like growth factor, which can contribute to the proliferation and differentiation of stem cells. Numerous studies have confirmed that PRF can significantly promote the proliferation and osteogenic differentiation of stem cells. Therefore, this paper reviews the progress of PRF development, preparation methods, structure and composition, and the effects of proliferation and osteogenic differentiation on stem cells.

Key words: Platelet-rich fibrin stem cells, Cell proliferation, Cell osteogenic differentiation

XU Fang-fang, YIN Li-hua. Research Progress on Effects of Platelet-rich Fibrin on Proliferation and Osteogenic Differentiation of Stem Cells.[J]. Journal of Oral Science Research, 2019, 35(6): 527-530.

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