Research Progress on Mechanism of Macrophages Affecting Bone Formation

doi:10.13701/j.cnki.kqyxyj.2021.11.002

Abstract

Abstract: Macrophages play a key role in bone formation, and their specific performance is regulated by multiple complex biological mechanisms. Specifically, certain signaling molecules secreted by macrophages, such as oncostatin M (OSM), prostaglandin E2 (PGE2), bone morphogenetic protein-2 (BMP-2), and tumor necrosis factor-α (TNF-α), have a key role in osteogenesis. In addition, polarized subtypes of macrophages also play a regulatory role at different stages of osteogenesis. This article reviews the research progress of the related mechanisms of macrophages influencing bone formation in recent years.

Key words: macrophages, osteogenesis, mesenchymal stem cells

NIE Zhangling, BAO Chongyun. Research Progress on Mechanism of Macrophages Affecting Bone Formation[J]. Journal of Oral Science Research, 2021, 37(11): 966-969.

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