Advancements of Stem Cell Composites in Prevention and Treatment of Iatrogenic Osteonecrosis of the Jaw

doi:10.13701/j.cnki.kqyxyj.2024.06.003

Abstract

Abstract: Medication-related osteonecrosis of the jaw (MRONJ) and osteoradionecrosis of the jaw (ORNJ) are two common and refractory iatrogenic osteonecrosis of the jaw, which pose significant clinical challenges. Given the swift progress in bone tissue engineering, the spotlight has shifted to stem cell composites comprised of biomaterials loaded with stem cells and their application in the prevention and treatment of MRONJ and ORNJ. This article reviews the pertinent researches on the prevention and treatment of MRONJ and ORNJ using stem cell composites. It elucidates the effects and influencing factors of stem cell composites in the context of preventing and treating MRONJ and ORNJ. Additionally, the article conducts an analysis of the unresolved issues within this technology, aiming to identify directions for future research endeavors and offering insights for clinical applications.

Key words: osteonecrosis of the jaw, stem cell, stem cell composite

SHI Keying, ZHENG Yuanna. Advancements of Stem Cell Composites in Prevention and Treatment of Iatrogenic Osteonecrosis of the Jaw[J]. Journal of Oral Science Research, 2024, 40(6): 484-488.

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